{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:56:25Z","timestamp":1792032985020,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Population\u2010based data on the epidemiology of vulvar lichen sclerosus (LS) are sparse and only few prospective studies have investigated the malignant potential of the disease. We used the nationwide Danish Pathology Registry to first assess the incidence of biopsy\u2010verified vulvar LS in the period 1997\u20132022 and second to examine the incidence of vulvar high\u2010grade squamous precancer and squamous cell carcinoma (SCC) in women with biopsy\u2010verified vulvar LS (1978\u20132019) compared with that expected in the general female population. For the latter aim, we computed standardized incidence ratios (SIRs) with 95% confidence intervals (CIs). During our study period, the age\u2010standardized incidence rate of vulvar LS increased from 5.0 (1997\u20131998) to 35.7 (2021\u20132022) per 100,000 person\u2010years. Compared with the general female population, women with biopsy\u2010verified vulvar LS had significantly increased rates of vulvar high\u2010grade squamous precancer (SIR\u2009=\u20098.5; 95% CI: 7.2\u201310.0) and SCC (SIR\u2009=\u200916.2; 95% CI: 14.2\u201318.4). The SIRs of vulvar high\u2010grade squamous precancer and SCC did not vary substantially according to length of follow\u2010up. This nationwide and population\u2010based study shows a 7\u2010fold increase in the incidence of biopsy\u2010verified vulvar LS since 1997. Data also show that women with biopsy\u2010verified vulvar LS have 8.5 and 16 times higher than expected incidence of vulvar high\u2010grade squamous precancer and SCC, respectively. The substantially increased incidence of vulvar high\u2010grade squamous precancer and SCC following LS is important in relation to the clinical management and follow\u2010up of LS patients.<\/jats:p>","DOI":"10.1002\/ijc.34927","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T07:43:58Z","timestamp":1711093438000},"page":"501-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Biopsy\u2010verified vulvar lichen sclerosus: Incidence trends 1997\u20132022 and increased risk of vulvar squamous precancer and squamous cell carcinoma"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5773-5169","authenticated-orcid":false,"given":"Louise","family":"Baandrup","sequence":"first","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Institute  Copenhagen Denmark"},{"name":"Department of Pathology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1679-6440","authenticated-orcid":false,"given":"Charlotte G.","family":"Hannibal","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Hertzum\u2010Larsen","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K.","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Institute  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Juliane Marie Centre, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2017.02.017"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2014.07.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13136"},{"issue":"7","key":"e_1_2_10_5_1","first-page":"477","article-title":"Prevalence of vulvar lichen sclerosus in a general gynecology practice","volume":"50","author":"Goldstein AT","year":"2005","journal-title":"J Reprod 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