{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:09:04Z","timestamp":1792123744514,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011727","name":"Stockholm l\u00e4ns landsting","doi-asserted-by":"publisher","award":["4\u20102645\/2015"],"award-info":[{"award-number":["4\u20102645\/2015"]}],"id":[{"id":"10.13039\/501100011727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["E0718301"],"award-info":[{"award-number":["E0718301"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2015\/649"],"award-info":[{"award-number":["CAN 2015\/649"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 21\u20100454 FE"],"award-info":[{"award-number":["CAN 21\u20100454 FE"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 21\u20101660"],"award-info":[{"award-number":["CAN 21\u20101660"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tamoxifen prevents recurrence of breast cancer and is also approved for preventive, risk\u2010reducing, therapy. Tamoxifen alters the breast tissue composition and decreases the mammographic density. We aimed to test if baseline breast tissue composition influences tamoxifen\u2010associated density change. This biopsy\u2010based study included 83 participants randomised to 6\u2009months daily intake of placebo, 20, 10, 5, 2.5, or 1\u2009mg tamoxifen. The study is nested within the double\u2010blinded tamoxifen dose\u2010determination trial Karolinska Mammography Project for Risk Prediction of Breast Cancer Intervention (KARISMA) Study. Ultrasound\u2010guided core\u2010needle breast biopsies were collected at baseline before starting treatment. Biopsies were quantified for epithelial, stromal, and adipose distributions, and epithelial and stromal expression of proliferation marker Ki67, oestrogen receptor (ER) and progesterone receptor (PR). Mammographic density was measured using STRATUS. We found that greater mammographic density at baseline was positively associated with stromal area and inversely associated with adipose area and stromal expression of ER. Premenopausal women had greater mammographic density and epithelial tissue, and expressed more epithelial Ki67, PR, and stromal PR, compared to postmenopausal women. In women treated with tamoxifen (1\u201320\u2009mg), greater density decrease was associated with higher baseline density, epithelial Ki67, and stromal PR. Women who responded to tamoxifen with a density decrease had on average 17% higher baseline density and a 2.2\u2010fold higher PR expression compared to non\u2010responders. Our results indicate that features in the normal breast tissue before tamoxifen exposure influences the tamoxifen\u2010associated density decrease, and that the age\u2010associated difference in density change may be related to age\u2010dependant differences in expression of Ki67 and PR.<\/jats:p>","DOI":"10.1002\/ijc.34939","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T14:30:35Z","timestamp":1711809035000},"page":"339-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Baseline breast tissue characteristics determine the effect of tamoxifen on mammographic density change"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-1556","authenticated-orcid":false,"given":"Marike","family":"Gabrielson","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Hammarstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Bergqvist","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Breast Centre, Department of Surgery Capio St G\u00f6rans Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"L\u00e5ng","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Diagnostic Radiology Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0066-0677","authenticated-orcid":false,"given":"Ann H.","family":"Rosendahl","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Oncology Lund University and Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Signe","family":"Borgquist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Oncology Lund University and Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Department of Oncology Aarhus University Hospital and Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanna","family":"Hellgren","sequence":"additional","affiliation":[{"name":"Department of Radiology S\u00f6dersjukhuset  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Czene","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Oncology South General Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71171-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60993-8"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2089-2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji372"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk050"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01535"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12010051"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0490"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1727-4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3877-x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34430"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.11.779"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02598"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.5015"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr079"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4690-5"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4768-0"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.9.670"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062790"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.21.1622"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0034"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.14904"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.6462"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191367098"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkac028"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-14-0252"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128861"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1992.122"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2005.04.014"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000130"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01332-4"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkz004"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.1.30"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697130500103458"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.2.171"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.108980"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2020.05.013"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2726-4"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-016-0779-0"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-015-0592-1"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1683"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-182"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11050387"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.33.14.1"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0558"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-023-01692-7"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117720"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.15.1170"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1408"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr622"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1346-0"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn063"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0798"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T04:52:58Z","timestamp":1733115178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,30]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,7,15]]}},"alternative-id":["10.1002\/ijc.34939"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34939","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,30]]},"assertion":[{"value":"2023-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}