{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T02:54:08Z","timestamp":1770692048989,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K12890"],"award-info":[{"award-number":["22K12890"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The most common toxicities associated with cyclin\u2010dependent kinase (CDK) 4\/6 inhibitor therapy include decreased leukopenia and neutropenia due to the inhibition of CDK6 of leukocyte and neutrophil precursors in bone marrow. These hematological toxicities are more commonly observed with palbociclib administration than with abemaciclib administration, which is approximately 13 times more selective against CDK4 than CDK6. Thus, even though both successfully inhibit CDK4\/6, the side effects of palbociclib and abemaciclib differ due to differences in selectivity. Recent reports have suggested an association between palbociclib and medication\u2010related osteonecrosis of the jaw; however, reports on this association are inconsistent. This study investigated the potential association of palbociclib and abemaciclib with MRONJ using the FAERS. Signals of \u201cOsteonecrosis of jaw\u201d were detected only in females using palbociclib (cROR<jats:sub>025<\/jats:sub>: 2.08). Other signals detected included stomatitis\u2010related adverse events with abemaciclib and intraoral soft tissue damage and infection with palbociclib. As previous exploratory studies have reported MRONJ signals for bisphosphonates and denosumab, we calculated the aROR for palbociclib\u2010induced osteonecrosis of the jaw using concomitant bisphosphonates and denosumab as covariates. A signal was detected even after adjusting for sex, age, and concomitant medications as covariates (aROR0<jats:sub>025<\/jats:sub>: 5.74). A proper understanding of the differences in CDK selectivity is necessary for the appropriate use of CDK4\/6 inhibitors. To the best of our knowledge, this is the first report on CDK4\/6 inhibitors and drug\u2010related osteonecrosis of the jaw. We believe that these results will offer new insights into adverse events related to the use of CDK4\/6 inhibitors, and may aid in the proper use of CDK4\/6 inhibitors.<\/jats:p>","DOI":"10.1002\/ijc.34962","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T12:23:30Z","timestamp":1713183810000},"page":"849-853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between CDK4\/6 inhibitors and drug\u2010related osteonecrosis of the jaw: A pharmacoepidemiological study using the FDA Adverse Events Reporting System"],"prefix":"10.1002","volume":"155","author":[{"given":"Makiko","family":"Go","sequence":"first","affiliation":[{"name":"Department of Pharmacy Ogaki Municipal Hospital  Ogaki\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-9604","authenticated-orcid":false,"given":"Yoshihiro","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmacy Gifu Pharmaceutical University  Gifu\u2010shi Japan"},{"name":"Laboratory of Medical Collaborative Pharmacy Gifu Pharmaceutical University  Gifu\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikuto","family":"Masuda","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmacy Gifu Pharmaceutical University  Gifu\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Ogaki Municipal Hospital  Ogaki\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department 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for adverse reactions in EudraVigilance (Accessed January 8 2024).https:\/\/www.ema.europa.eu\/en\/documents\/other\/screening-adverse-reactions-eudravigilance_en.pdf."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264\u2010024\u201001404\u2010w"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238\u2010018\u20100548\u20101"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4801315"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.606043"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2693"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360\u2010023\u201000657\u2010y"}],"container-title":["International Journal of 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