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However, studies conducted in Asian countries are limited. This project considered data of 968,738 adults pooled from 20 cohort studies of Asia Cohort Consortium to examine the association between baseline diabetes and liver cancer incidence and mortality. Cox proportional hazard model and competing risk approach was used for pooled data. Two\u2010stage meta\u2010analysis across studies was also done. There were 839,194 subjects with valid data regarding liver cancer incidence (5654 liver cancer cases [48.29\/100,000 person\u2010years]), follow\u2010up time and baseline diabetes (44,781 with diabetes [5.3%]). There were 747,198 subjects with valid data regarding liver cancer mortality (5020 liver cancer deaths [44.03\/100,000 person\u2010years]), follow\u2010up time and baseline diabetes (43,243 with diabetes [5.8%]). Hazard ratio (HR) (95% confidence interval [95%CI]) of liver cancer diagnosis in those with vs. without baseline diabetes was 1.97 (1.79, 2.16) (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) after adjusting for baseline age, gender, body mass index, tobacco smoking, alcohol use, and heterogeneity across studies (<jats:italic>n<\/jats:italic>\u2009=\u2009586,072; events\u2009=\u20094620). Baseline diabetes was associated with increased cumulative incidence of death due to liver cancer (adjusted HR (95%CI)\u2009=\u20091.97 (1.79, 2.18); <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) (<jats:italic>n<\/jats:italic>\u2009=\u2009595,193; events\u2009=\u20094110). A two\u2010stage meta\u2010analytic approach showed similar results. This paper adds important population\u2010based evidence to current literature regarding the increased incidence and mortality of liver cancer in adults with diabetes. The analysis of data pooled from 20 studies of different Asian countries and the meta\u2010analysis across studies with large number of subjects makes the results robust.<\/jats:p>","DOI":"10.1002\/ijc.34965","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T12:30:14Z","timestamp":1714048214000},"page":"854-870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7898-0956","authenticated-orcid":false,"given":"Nhan Thi","family":"Ho","sequence":"first","affiliation":[{"name":"Research Management Department Vinmec Healthcare System  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3991-2739","authenticated-orcid":false,"given":"Sarah Krull","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Prevention National Cancer Center Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-6807","authenticated-orcid":false,"given":"Md. 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