{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:38:37Z","timestamp":1775018317939,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03906"],"award-info":[{"award-number":["20H03906"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Japan is lagging in cervical cancer prevention. The effectiveness of a self\u2010sampling human papillomavirus (HPV) test, a possible measure to overcome this situation, has not yet been evaluated. A randomized controlled trial was performed to evaluate the effectiveness of a self\u2010sampling HPV test on detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and screening uptake. Women between 30 and 58\u2009years old who did not participate in the cervical cancer screening program for \u22653\u2009years were eligible and assigned to the intervention group (cytology or self\u2010sampling HPV test) or control group (cytology). Participants assigned to the intervention group were sent a self\u2010sampling kit according to their ordering (opt\u2010in strategy). A total of 7337 and 7772 women were assigned to the intervention and control groups, respectively. Screening uptake in the intervention group was significantly higher than that in the control group (20.0% vs. 6.4%; risk ratio: 3.10; 95% confidence interval [CI]: 2.82, 3.42). The compliance rate with cytology triage for HPV\u2010positive women was 46.8% (95% CI: 35.5%, 58.4%). CIN2+ was detected in five and four participants in the intervention and control groups, respectively; there was no difference for intention\u2010to\u2010screen analysis (risk ratio: 1.32; 95% CI: 0.36, 4.93). Self\u2010sampling of HPV test increased screening uptake; however, no difference was observed in the detection of CIN2+, probably due to the low compliance rate for cytology triage in HPV\u2010positive women. Efforts to increase cytology triage are essential to maximize precancer detections.<\/jats:p>","DOI":"10.1002\/ijc.34970","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T18:33:47Z","timestamp":1713810827000},"page":"905-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of self\u2010sampling human papillomavirus test on precancer detection and screening uptake in <scp>Japan<\/scp>: The <scp>ACCESS<\/scp> randomized controlled trial"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5308-4744","authenticated-orcid":false,"given":"Misuzu","family":"Fujita","sequence":"first","affiliation":[{"name":"Department of Health Research Chiba Foundation for Health Promotion and Disease Prevention  Chiba Japan"},{"name":"Department of Public Health Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-9045","authenticated-orcid":false,"given":"Kengo","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Clinical and Translational Research Center Keio University Hospital  Shinjuku\u2010ku Japan"},{"name":"Research Center for Medical and Health Data Science The Institute of Statistical Mathematics  Tachikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minobu","family":"Shimazu","sequence":"additional","affiliation":[{"name":"Clinical Research Center Chiba University Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misae","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Municipal Health Center  Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Tauchi","sequence":"additional","affiliation":[{"name":"Municipal Health Center  Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwa","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Municipal Health Center  Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Municipal Health Center  Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"Clinical Research Center Chiba University Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makio","family":"Shozu","sequence":"additional","affiliation":[{"name":"Evolution and Reproduction Biology, Medical Mycology Research Center Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhide","family":"Tsuruoka","sequence":"additional","affiliation":[{"name":"Yushudai Clinic  Ichihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokuzo","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Health Research Chiba Foundation for Health Promotion and Disease Prevention  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Health Research Chiba Foundation for Health Promotion and Disease Prevention  Chiba Japan"},{"name":"Center for Preventive Medical Sciences Chiba University  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"National Cancer Center Japan.Statistics by cancer type: cervical. 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