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This study aimed to elucidate the genetic and clinical characteristics of patients with SGC using the Center for Cancer Genomics and Advanced Therapeutics (C\u2010CAT) database, a Japanese national genomic database. We analyzed data of 776 patients with SGC registered in the C\u2010CAT database between June 1, 2019, and June 30, 2023. Adenoid cystic carcinoma was the most common histologic type, followed by salivary duct carcinoma (SDC) and adenocarcinoma not otherwise specified. Genetic data of 681 patients receiving FoundationOne\u00ae CDx were analyzed. We identified specific features of the combination of <jats:italic>TP53<\/jats:italic> and <jats:italic>CDKN2A<\/jats:italic> alterations among the histological types. Specific <jats:italic>LYN<\/jats:italic> amplification was mainly detected in carcinoma ex pleomorphic adenoma and myoepithelial carcinoma. For SDC, the frequency of <jats:italic>ERBB2<\/jats:italic> and <jats:italic>BRAF<\/jats:italic> alterations were higher in cases with metastatic lesions than in those with primary lesions. Although 28.6% patients were offered recommended treatment options, only 6.8% received the recommended treatments. This study highlights the differences in genetic alterations among the histological types of SGC, with comprehensive genomic profiling tests revealing lower drug accessibility. These findings could contribute to the development of personalized treatment for patients with SGC.<\/jats:p>","DOI":"10.1002\/ijc.34972","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T08:20:48Z","timestamp":1714465248000},"page":"871-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comprehensive genomic profiling of salivary gland carcinoma: Analysis of the Center for Cancer Genomics and Advanced Therapeutics database in Japan"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1808-6941","authenticated-orcid":false,"given":"Sho","family":"Iwaki","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"},{"name":"Department of Pathology and Molecular Diagnosis Nagoya City University Graduate School of Medical Sciences  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