{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:02:34Z","timestamp":1790794954519,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010711","name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with primary hematological malignancy (HM) are at an elevated risk of subsequent malignant neoplasms (SMNs), which is a common concern after treatment of primary cancer. We identified 45,533 patients aged \u226520\u2009years and diagnosed with primary HM in Finland from 1992 to 2019 from the Finnish Cancer Registry and estimated standardized incidence ratios (SIR) and excess absolute risks per 1000 person\u2010years (EAR) for SMNs. A total of 6076 SMNs were found (4604 solid and 1472 hematological SMNs). The SIRs were higher for hematological SMNs (SIR 4.9, 95% confidence interval [CI] 4.7\u20135.2) compared to solid SMNs (SIR 1.5, 95% CI 1.4\u20131.5). The SIRs for hematological SMNs were highest in the young HM patients aged 20\u201339\u2009years (SIR 9.2, 95% CI 6.8\u201312.2 in males and SIR 10.5, 95% CI 7.2\u201314.7 in females) and decreased by age of first primary HM. However, EARs for hematological SMNs were highest in the older patients, aged 60\u201379\u2009years at their first primary HM (EAR 5.7\/1000 and 4.7\/1000 in male and female patients, respectively). In conclusion, the incidence of both hematological and solid SMNs were increased in hematological cancer patients. The relative risk (SIR) was highest among younger HM patients with hematological SMNs. The absolute second cancer burden reflected by high EAR arises from solid malignancies in older patients. Our results accentuate the need for vigilance in the surveillance of HM patients.<\/jats:p>","DOI":"10.1002\/ijc.34973","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T03:58:31Z","timestamp":1714103911000},"page":"1007-1013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Subsequent malignant neoplasms after primary hematological malignancy in adult patients"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0269-0167","authenticated-orcid":false,"given":"Rosa M.","family":"R\u00f6nkk\u00f6","sequence":"first","affiliation":[{"name":"Finnish Cancer Registry, Cancer Society of Finland  Helsinki Finland"},{"name":"Department of Internal Medicine Helsinki University Hospital Physical Medicine and Rehabilitation  Helsinki Finland"},{"name":"Department of Hematology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aapeli O.","family":"Nevala","sequence":"additional","affiliation":[{"name":"Finnish Cancer Registry, Cancer Society of Finland  Helsinki Finland"},{"name":"Department of Mathematics and Statistics University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne M.","family":"Pitk\u00e4niemi","sequence":"additional","affiliation":[{"name":"Finnish Cancer Registry, Cancer Society of Finland  Helsinki Finland"},{"name":"Faculty of Social Sciences Tampere University  Tampere Finland"},{"name":"Department of Public Health, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla M.","family":"Wartiovaara\u2010Kautto","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Helsinki  Helsinki Finland"},{"name":"Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki  Helsinki Finland"},{"name":"Department of Hematology Helsinki University Hospital Comprehensive Cancer Center  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nea K.","family":"Malila","sequence":"additional","affiliation":[{"name":"Finnish Cancer Registry, Cancer Society of Finland  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29096"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.41"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.167478"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006369"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31801"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602654"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.6068"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.1112"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26363"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194919"},{"issue":"5","key":"e_1_2_9_12_1","first-page":"1","article-title":"Effect of autologous hematopoietic stem cell transplant on the development of second primary malignancies in multiple myeloma patients","volume":"11","author":"Rosenberg AS","year":"2021","journal-title":"Blood Cancer J"},{"issue":"1","key":"e_1_2_9_13_1","first-page":"1","article-title":"Second malignancies in multiple myeloma; 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