{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:52:50Z","timestamp":1789876370168,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ 01KI20152"],"award-info":[{"award-number":["FKZ 01KI20152"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunocompromised patients are at high risk to fail clearance of SARS\u2010CoV\u20102. Prolonged COVID\u201019 constitutes a health risk and a management problem as cancer treatments often have to be disrupted. As SARS\u2010CoV\u20102 evolves, new variants of concern have emerged that evade available monoclonal antibodies. Moreover, antiviral therapy promotes SARS\u2010CoV\u20102 escape mutations, particularly in immunocompromised patients. These patients frequently suffer from prolonged infection. No successful treatment has been established for persistent COVID\u201019 infection. Here, we report on a series of 21 immunocompromised patients with COVID\u201019\u2014most of them hematologic malignancies\u2014treated with plasma obtained from recently convalescent or vaccinated donors or a combination thereof. Repeated dosing of SARS\u2010CoV\u20102\u2010antibody\u2010containing plasma could clear SARS\u2010CoV\u20102 infection in 16 out of 21 immunocompromised patients even if COVID\u201019\u2010specific treatments failed to induce sustained viral clearance or to improve clinical course of SARS\u2010CoV\u20102 infection. Ten patients were major responders defined as an increase delta(<jats:italic>d<\/jats:italic>)<jats:italic>Ct<\/jats:italic> of &gt;\u2009=\u20095 after the first administration of convalescent and\/or vaccinated plasma (C\/VP). On average, SARS\u2010CoV\u20102 PCR <jats:italic>Ct<\/jats:italic> values increased from a median value of 22.55 (IQR\u2009=\u200919.10\u201324.25) to a median value of 29.57 (IQR\u2009=\u200927.55\u201334.63; <jats:italic>p<\/jats:italic>\u2009=\u2009&lt;.0001) in the major response subgroup. Furthermore, when treated a second time with C\/VP, even 4 out of 5 of the initial nonresponders showed an increase in <jats:italic>Ct<\/jats:italic>\u2010values from a median value of 23.13 (IQR\u2009=\u200917.75\u201328.05) to a median value of 32.79 (IQR\u2009=\u200931.75\u201333.75; <jats:italic>p<\/jats:italic>\u2009=\u2009.013). Our results suggest that C\/VP could be a feasible treatment of COVID\u201019 infection in patients with hematologic malignancies who did not respond to antiviral treatment.<\/jats:p>","DOI":"10.1002\/ijc.34988","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T09:09:56Z","timestamp":1715245796000},"page":"618-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Treatment of chronic <scp>COVID<\/scp>\u201019 with convalescent\/postvaccination plasma in patients with hematologic malignancies"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-1022","authenticated-orcid":false,"given":"Maike","family":"Janssen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine V Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Leo","sequence":"additional","affiliation":[{"name":"Institute for Clinical Transfusion Medicine and Cell Therapy Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Wolf","sequence":"additional","affiliation":[{"name":"Institute for Clinical Transfusion Medicine and Cell Therapy Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Stenzinger","sequence":"additional","affiliation":[{"name":"Institute for Clinical Transfusion Medicine and Cell Therapy Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bartenschlager","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Molecular Virology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1579-1509","authenticated-orcid":false,"given":"Michael","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dreger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Schlenk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Heidelberg University Hospital  Heidelberg Germany"},{"name":"NCT\u2010Trial Center, National Center of Tumor Diseases Heidelberg University Hospital and German Cancer Research Center  Heidelberg Germany"},{"name":"National Center for Tumor Diseases (NCT)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia M.","family":"Denkinger","sequence":"additional","affiliation":[{"name":"Division of Tropical Medicine, Department of Infectious Diseases Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"M\u00fcller\u2010Tidow","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V Heidelberg University Hospital  Heidelberg Germany"},{"name":"National Center for 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Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T11:05:32Z","timestamp":1718795132000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8,15]]}},"alternative-id":["10.1002\/ijc.34988"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34988","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]},"assertion":[{"value":"2023-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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