{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:27:23Z","timestamp":1792016843306,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103084"],"award-info":[{"award-number":["82103084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The primary objective of this study is to develop a prediction model for peritoneal metastasis (PM) in colorectal cancer by integrating the genomic features of primary colorectal cancer, along with clinicopathological features. Concurrently, we aim to identify potential target implicated in the peritoneal dissemination of colorectal cancer through bioinformatics exploration and experimental validation. By analyzing the genomic landscape of primary colorectal cancer and clinicopathological features from 363 metastatic colorectal cancer patients, we identified 22 differently distributed variables, which were used for subsequent LASSO regression to construct a PM prediction model. The integrated model established by LASSO regression, which incorporated two clinicopathological variables and seven genomic variables, precisely discriminated PM cases (AUC 0.899; 95% CI 0.860\u20130.937) with good calibration (Hosmer\u2013Lemeshow test <jats:italic>p<\/jats:italic>\u2009=\u2009.147). Model validation yielded AUCs of 0.898 (95% CI 0.896\u20130.899) and 0.704 (95% CI 0.622\u20130.787) internally and externally, respectively. Additionally, the peritoneal metastasis\u2010related genomic signature (PGS), which was composed of the seven genes in the integrated model, has prognostic stratification capability for colorectal cancer. The divergent genomic landscape drives the driver genes of PM. Bioinformatic analysis concerning these driver genes indicated <jats:italic>SERINC1<\/jats:italic> may be associated with PM. Subsequent experiments indicate that knocking down of <jats:italic>SERINC1<\/jats:italic> functionally suppresses peritoneal dissemination, emphasizing its importance in CRCPM. In summary, the genomic landscape of primary cancer in colorectal cancer defines peritoneal metastatic pattern and reveals the potential target of <jats:italic>SERINC1<\/jats:italic> for PM in colorectal cancer.<\/jats:p>","DOI":"10.1002\/ijc.35005","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T13:33:40Z","timestamp":1715607220000},"page":"1327-1339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genomic landscape defines peritoneal metastatic pattern and related target of peritoneal metastasis in colorectal cancer"],"prefix":"10.1002","volume":"155","author":[{"given":"Minhui","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Endoscopy, The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou 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Pelvic Floor Diseases, Biomedical Innovation Center, The Sixth Affiliated Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5475-7736","authenticated-orcid":false,"given":"Mingming","family":"Yuan","sequence":"additional","affiliation":[{"name":"Geneplus\u2010Beijing, Medical Park Road Zhongguancun Life Science Park  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Chen","sequence":"additional","affiliation":[{"name":"Geneplus\u2010Beijing, Medical Park Road Zhongguancun Life Science Park  Beijing 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