{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:13:49Z","timestamp":1771049629843,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021070","name":"Fondazione Arpa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008658","name":"Deutsches Krebsforschungszentrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["FIMP_ CUP J37G22000230001"],"award-info":[{"award-number":["FIMP_ CUP J37G22000230001"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente 2022\u20102024"],"award-info":[{"award-number":["Ricerca Corrente 2022\u20102024"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Correlated regions of systemic interindividual variation (CoRSIV) represent a small proportion of the human genome showing DNA methylation patterns that are the same in all human tissues, are different among individuals, and are partially regulated by genetic variants in\n                    <jats:italic>cis<\/jats:italic>\n                    . In this study we aimed at investigating single\u2010nucleotide polymorphisms (SNPs) within CoRSIVs and their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV\u2010SNPs and 133,615 CoRSIV\u2010mQTLs in 14,394 cases and 247,022 controls of European and Asian descent. We observed that the A allele of the rs2976395 SNP was associated with increased PDAC risk in Europeans (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20092.81\u2009\u00d7\u200910\n                    <jats:sup>\u22125<\/jats:sup>\n                    ). This SNP lies in the prostate stem cell antigen gene and is in perfect linkage disequilibrium with a variant (rs2294008) that has been reported to be associated with risk of many other cancer types. The A allele is associated with the DNA methylation level of the gene according to the PanCan\u2010meQTL database and with overexpression according to QTLbase. The expression of the gene has been observed to be deregulated in many tumors of the gastrointestinal tract including pancreatic cancer; however, functional studies are needed to elucidate the function relevance of the association.\n                  <\/jats:p>","DOI":"10.1002\/ijc.35046","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T10:18:41Z","timestamp":1719397121000},"page":"1432-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Potential association between\n                    <scp>\n                      <i>PSCA<\/i>\n                      rs2976395\n                    <\/scp>\n                    functional variant and pancreatic cancer risk"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-9803","authenticated-orcid":false,"given":"Chiara","family":"Corradi","sequence":"first","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Lencioni","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4116-0203","authenticated-orcid":false,"given":"Alessio","family":"Felici","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-2178","authenticated-orcid":false,"given":"Cosmeri","family":"Rizzato","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-9653","authenticated-orcid":false,"given":"Manuel","family":"Gentiluomo","sequence":"additional","affiliation":[{"name":"Department of Biology University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Ermini","sequence":"additional","affiliation":[{"name":"Blood Transfusion Service Azienda Ospedaliera\u2010Universitaria Meyer, Children's Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Archibugi","sequence":"additional","affiliation":[{"name":"Pancreato\u2010Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center IRSSC San Raffaele Scientific Institute  Milan Italy"},{"name":"Digestive and Liver Disease Unit Sant'Andrea Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antanas","family":"Mickevicius","sequence":"additional","affiliation":[{"name":"Department of Surgery Lithuanian University of Health Sciences  Kaunas Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Lucchesi","sequence":"additional","affiliation":[{"name":"Oncology of Massa Carrara, Oncological Department Azienda USL Toscana Nord Ovest  Carrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Malecka\u2010Wojciesko","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Diseases Medical University of Lodz  Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Basso","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, Department DIMED University of Padova  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo Giorgio","family":"Arcidiacono","sequence":"additional","affiliation":[{"name":"Pancreato\u2010Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center IRSSC San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Petrone","sequence":"additional","affiliation":[{"name":"Pancreato\u2010Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center IRSSC San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Carrara","sequence":"additional","affiliation":[{"name":"Endoscoopic Unit, Gastroenterology Department IRCCS Humanitas Research Hospital  Rozzano, Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery 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Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Theodoropoulos","sequence":"additional","affiliation":[{"name":"First Propaedeutic University Surgery Clinic, Hippocratio General Hospital, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina Gloria Giulia","family":"Testoni","sequence":"additional","affiliation":[{"name":"Pancreato\u2010Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center IRSSC San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kestutis","family":"Adamonis","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Institute for Digestive Research Lithuanian University of Health Sciences  Kaunas Lithuania"},{"name":"Department of Surgery, Amsterdam UMC University of Amsterdam, Cancer Center Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Neoptolemos","sequence":"additional","affiliation":[{"name":"First Propaedeutic University Surgery Clinic, Hippocratio General Hospital, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-6811","authenticated-orcid":false,"given":"Maria","family":"Gazouli","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Laboratory of Biology, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Pasquali","sequence":"additional","affiliation":[{"name":"Department of DiSCOG University of Padova  Padua 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