{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:07:37Z","timestamp":1793729257851,"version":"4.6.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007210","name":"Varian Medical Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Metastasis\u2010directed therapy (MDT) for oligometastatic prostate cancer (PCa), including stereotactic body radiotherapy (SBRT), has shown promise but is still considered investigational. This is the 5\u2010year analysis of the TRANSFORM trial, the largest prospective cohort of men with oligometastatic PCa treated with SBRT\u2010based MDT. The primary endpoint was 5\u2010year treatment escalation\u2010free survival (TE\u2010FS), defined as freedom from any new cancer therapy other than further SBRT. In total, 199 men received SBRT; 76.4% were hormone\u2010na\u00efve at baseline. The rate of 5\u2010year TE\u2010FS was 21.7% (95% confidence interval [CI]: 15.7%\u201328.7%) overall and 25.4% (95% CI: 18.1%\u201333.9%) in the hormone\u2010na\u00efve subgroup. The subgroups with International Society of Urological Pathology Grade Groups 4\u20135 disease (hazard ratio [HR]\u2009=\u20091.48, 95% CI: 1.05\u20132.01, <jats:italic>p<\/jats:italic>\u2009=\u2009.026), a higher baseline prostate\u2010specific antigen (PSA) (HR\u2009=\u20091.06, 95% CI: 1.03\u20131.09, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and those who received prior androgen deprivation therapy (ADT) (HR\u2009=\u20092.13, 95% CI: 1.40\u20133.26, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), were at greater risk of treatment escalation. Outcomes for participants with four or five initial lesions were comparable to those with one to three lesions. At last follow\u2010up, 18.9% (95% CI: 13.2%\u201325.7%) of participants were free from treatment escalation (median follow\u2010up of 67.9\u2009months) and two participants had an undetectable PSA level. No treatment\u2010related grade three or higher adverse events were reported. The findings of this study demonstrate that SBRT\u2010based MDT is an effective option for delaying systemic treatment escalation in the context of oligometastatic PCa. Future randomised trials comparing SBRT\u2010based MDT to standard\u2010of\u2010care ADT\u2010based approaches are required to evaluate the impact of delaying ADT on survival.<\/jats:p>","DOI":"10.1002\/ijc.35052","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T04:53:16Z","timestamp":1718859196000},"page":"1248-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Five\u2010year outcomes of fractionated stereotactic body radiotherapy for oligometastatic prostate cancer from the <scp>TRANSFORM<\/scp> phase <scp>II<\/scp> trial"],"prefix":"10.1002","volume":"155","author":[{"given":"Andrew W.","family":"See","sequence":"first","affiliation":[{"name":"Icon Cancer Centre  Richmond Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Conway","sequence":"additional","affiliation":[{"name":"Icon Cancer Centre  Richmond Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Frydenberg","sequence":"additional","affiliation":[{"name":"Department of Surgery Monash University  Melbourne Victoria Australia"},{"name":"Australian Urology Associates  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hodo","family":"Haxhimolla","sequence":"additional","affiliation":[{"name":"Department of Urology The Canberra Hospital  Canberra Australian Capital Territory Australia"},{"name":"College of Health and Medicine Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Costello","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Melbourne  Parkville Victoria Australia"},{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Epworth HealthCare  Richmond Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ruljancich","sequence":"additional","affiliation":[{"name":"Epworth Eastern  Box Hill Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Grummet","sequence":"additional","affiliation":[{"name":"Epworth HealthCare  Richmond Victoria Australia"},{"name":"Department of Surgery, Central Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganes","family":"Pranavan","sequence":"additional","affiliation":[{"name":"College of Health and Medicine Australian National University  Canberra Australian Capital Territory Australia"},{"name":"Department of Medical Oncology The Canberra Hospital  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Melbourne  Parkville Victoria Australia"},{"name":"Epworth HealthCare  Richmond Victoria Australia"},{"name":"Department of Urology Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-5807","authenticated-orcid":false,"given":"Lloyd M. 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