{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:13:56Z","timestamp":1787505236695,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA269764"],"award-info":[{"award-number":["1R01CA269764"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR180061"],"award-info":[{"award-number":["RR180061"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multiple myeloma (MM) is a heterogeneous disease with a small subset of high\u2010risk patients having poor prognoses. Identifying these patients is crucial for treatment management and strategic decisions. In this study, we developed a novel computational framework to define prognostic gene signatures by selecting genes with expression driven by clonal copy number alterations. We applied this framework to MM and developed a clonal gene signature (CGS) consisting of 22 genes and evaluated in five independent datasets. The CGS provided significant prognostic values after adjusting for well\u2010established factors including cytogenetic abnormalities, International Staging System (ISS), and Revised ISS (R\u2010ISS). Importantly, CGS demonstrated higher performance in identifying high\u2010risk patients compared to the GEP70 and SKY92 signatures recommended for prognostic stratification of MM. CGS can further stratify patients into subgroups with significantly differential prognoses when applied to the high\u2010 and low\u2010risk groups identified by GEP70 and SKY92. Additionally, CGS scores are significantly associated with patient response to dexamethasone, a commonly used treatment for MM. In summary, we proposed a computational framework that requires only gene expression data to identify CGSs for prognosis prediction. CGS provides a useful biomarker for improving prognostic stratification in MM, especially for identifying the highest\u2010risk patients.<\/jats:p>","DOI":"10.1002\/ijc.35057","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T09:08:47Z","timestamp":1718356127000},"page":"1684-1695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identifying high\u2010risk multiple myeloma patients: A novel approach using a clonal gene signature"],"prefix":"10.1002","volume":"155","author":[{"given":"Jian\u2010Rong","family":"Li","sequence":"first","affiliation":[{"name":"Institute for Clinical and Translational Research Baylor College of Medicine  Houston Texas USA"},{"name":"Section of Epidemiology and Population Sciences, Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Wang","sequence":"additional","affiliation":[{"name":"Genetics and Genomics Graduate Program Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5002-3417","authenticated-orcid":false,"given":"Chao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Research Baylor College of Medicine  Houston Texas USA"},{"name":"Section of Epidemiology and Population Sciences, Department of Medicine Baylor College of Medicine  Houston Texas USA"},{"name":"Dan L Duncan Comprehensive Cancer Center Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci9010003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.282"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_200879"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201010\u2010300970"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.016436"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.247"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010022\u201000679\u20105"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2014.47136"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030648"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000313"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100595\u2010z"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.532.532"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1607591"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003323"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1665"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201009\u2010044974"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201012\u2010261032"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201007\u2010038430"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.127"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201005\u2010644039"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010021\u201000819\u2010w"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010021\u201002540\u20107"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201014\u20107"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1028"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyad031"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.956"},{"key":"e_1_2_9_32_1","unstructured":"GerdsTA OhlendorffJS BlancheP et al.riskRegression: Risk Regression Models and Prediction Scores for Survival Analysis with Competing Risks. Accessed May 18 2024.https:\/\/cran.r-project.org\/web\/packages\/riskRegression\/index.html"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752\u20100509\u20105\u2010121"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010019\u20100620\u20106"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001547\u20108"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1861"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004309"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755\u20108794\u20107\u201025"},{"issue":"11","key":"e_1_2_9_39_1","first-page":"1498","article-title":"Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: results of an IFM phase II study","volume":"91","author":"Harousseau JL","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010020\u201000312\u20106"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082203"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2018.04"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6020066"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4616"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201049133\u2010w"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010022\u201009872\u2010y"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.30102"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201016\u20100867"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2020.S008"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174320"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.52"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2022.2136950"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.35057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T07:06:41Z","timestamp":1731827201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.35057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/ijc.35057"],"URL":"https:\/\/doi.org\/10.1002\/ijc.35057","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]},"assertion":[{"value":"2024-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}