{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:40:28Z","timestamp":1783615228485,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001792","name":"James Cook University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Epstein\u2013Barr virus (EBV) is an oncogenic virus associated with various malignancies, including classical Hodgkin lymphoma (cHL). Despite its known association, the specific role of humoral immune response to EBV remains poorly characterized in cHL. To address this, we conducted a study using a custom protein microarray to measure the antibody responses in cHL patients and matched healthy controls recruited from an East\u2010Asian hospital\u2010based case\u2013control study. We identified 16 IgG antibodies significantly elevated in EBV\u2010positive cHL compared with controls, defining an \u201cEast\u2010Asian antibody signature of EBV\u2010positive cHL.\u201d We evaluated responses against these 16 antibodies in a distinct European population, leveraging data from our previous European cHL case\u2013control study from the UK, Denmark, and Sweden. A subset of antibodies (14\/16, 87.5%) from the \u201cEast\u2010Asian antibody signature of EBV\u2010positive cHL\u201d exhibited significant associations with cHL in the European population. Conversely, we assessed the \u201cEuropean antibody signature of EBV\u2010positive cHL\u201d identified in our prior study which consisted of 18 EBV antibodies (2 IgA, 16 IgG), in the East\u2010Asian population. A subset of these antibodies (15\/18, 83.3%) maintained significant associations with cHL in the East\u2010Asian population. This cross\u2010comparison of antibody signatures underscores the robust generalizability of EBV antibodies across populations. Five anti\u2010EBV IgG antibodies (LMP\u20101, TK, BALF2, BDLF3, and BBLF1), found in both population\u2010specific antibody signatures, represent a \u201ccore signature of EBV\u2010positive cHL.\u201d Our findings suggest that the antibody responses targeting these core EBV proteins reflect a specific EBV gene expression pattern, serving as potential biomarkers for EBV\u2010positive cHL independent of population\u2010specific factors.<\/jats:p>","DOI":"10.1002\/ijc.35072","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T09:31:16Z","timestamp":1720776676000},"page":"1476-1486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A proteome\u2010wide analysis unveils a core\n                    <scp>Epstein\u2013Barr<\/scp>\n                    virus antibody signature of classic\n                    <scp>Hodgkin<\/scp>\n                    lymphoma across ethnically diverse populations"],"prefix":"10.1002","volume":"155","author":[{"given":"Yomani D.","family":"Sarathkumara","sequence":"first","affiliation":[{"name":"Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine James Cook University  Cairns Queensland Australia"},{"name":"Institute for Molecular Bioscience The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rena R.","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncology Johns Hopkins University, School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0136-651X","authenticated-orcid":false,"given":"Zhiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3832-6586","authenticated-orcid":false,"given":"Kelly J.","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K. C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology Queen Elizabeth Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yok\u2010Lam","family":"Kwong","sequence":"additional","affiliation":[{"name":"Queen Mary Hospital The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai Hing","family":"Lam","sequence":"additional","affiliation":[{"name":"School of Public Health, Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Liang","sequence":"additional","affiliation":[{"name":"Hong Kong Sanatorium &amp; Hospital  Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Health Studies University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu\u2010Tian","family":"Ji","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-7499","authenticated-orcid":false,"given":"Anna E.","family":"Coghill","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program, Division of Population Sciences H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine James Cook University  Cairns Queensland Australia"},{"name":"Institute for Molecular Bioscience The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-2698","authenticated-orcid":false,"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-9943","authenticated-orcid":false,"given":"Nathaniel","family":"Rothman","sequence":"additional","affiliation":[{"name":"Division 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