{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:50:18Z","timestamp":1789062618050,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The overall survival (OS) improvement after the advent of several novel systemic therapies, designed for treatment of metastatic urothelial carcinoma of the urinary bladder (mUCUB), is not conclusively studied in either contemporary UCUB patients and\/or non\u2010UCUB patients. Within the Surveillance, Epidemiology, and End Results database, contemporary (2017\u20132020) and historical (2000\u20132016) systemic therapy\u2010exposed metastatic UCUB and, subsequently, non\u2010UCUB patients were identified. Separate Kaplan\u2013Meier and multivariable Cox regression (CRM) analyses first addressed OS in mUCUB and, subsequently, in metastatic non\u2010UCUB (mn\u2010UCUB). Of 3443 systemic therapy\u2010exposed patients, 2725 (79%) harbored mUCUB versus 709 (21%) harbored mn\u2010UCUB. Of 2725 mUCUB patients, 582 (21%) were contemporary (2017\u20132020) versus 2143 (79%) were historical (2000\u20132016). In mUCUB, median OS was 11\u2009months in contemporary versus 8\u2009months in historical patients (\n                    <jats:italic>\u0394<\/jats:italic>\n                    \u2009=\u20093\u2009months;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.0001). After multivariable CRM, contemporary membership status (2017\u20132020) independently predicted lower overall mortality (OM; hazard ratio [HR] =\u20090.68, 95% confidence interval [CI] =\u20090.60\u20130.76;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001). Of 709 mn\u2010UCUB patients, 167 (24%) were contemporary (2017\u20132020) and 542 (76%) were historical (2000\u20132016). In mn\u2010UCUB, median OS was 8\u2009months in contemporary versus 7\u2009months in historical patients (\n                    <jats:italic>\u0394<\/jats:italic>\n                    \u2009=\u20091\u2009month;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.034). After multivariable CRM, contemporary membership status (2017\u20132020) was associated with HR of 0.81 (95% CI\u2009=\u20090.66\u20131.01;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.06). In conclusion, contemporary systemic therapy\u2010exposed metastatic patients exhibited better OS in UCUB. However, the magnitude of survival benefit was threefold higher in mUCUB and approximated the survival benefits recorded in prospective randomized trials of novel systemic therapies.\n                  <\/jats:p>","DOI":"10.1002\/ijc.35077","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T08:00:42Z","timestamp":1719993642000},"page":"1762-1768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Contemporary survival in metastatic bladder cancer patients: A population\u2010based study"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8585-3701","authenticated-orcid":false,"given":"Francesco","family":"Di Bello","sequence":"first","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Siech","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology University Hospital, Goethe University Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0612-0519","authenticated-orcid":false,"given":"Letizia Maria Ippolita","family":"Jannello","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology IEO European Institute of Oncology, IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"de Angelis","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natali","family":"Rodriguez Pe\u00f1aranda","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology, Ospedale Policlinico e Nuovo Ospedale Civile S. Agostino Estense Modena University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Tian","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan A.","family":"Goyal","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Baudo","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Urology IRCCS Policlinico San Donato  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Coll\u00e0 Ruvolo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Califano","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Creta","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[{"name":"Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montr\u00e9al Health Center  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrokh F.","family":"Shariat","sequence":"additional","affiliation":[{"name":"Department of Urology, Comprehensive Cancer Center Medical University of Vienna  Vienna Austria"},{"name":"Department of Urology Weill Cornell Medical College  New York New York USA"},{"name":"Department of Urology University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Hourani Center for Applied Scientific Research Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Acquati","sequence":"additional","affiliation":[{"name":"Department of Urology IRCCS Policlinico San Donato  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio","family":"de Cobelli","sequence":"additional","affiliation":[{"name":"Department of Urology IEO European Institute of Oncology, IRCCS  Milan Italy"},{"name":"Department of Urology Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Briganti","sequence":"additional","affiliation":[{"name":"Department of Urology Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"Division of Experimental Oncology\/Unit of Urology, URI, Urological Research Institute IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix K. 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