{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:16:17Z","timestamp":1782278177778,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["259332240\/RTG 2099"],"award-info":[{"award-number":["259332240\/RTG 2099"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated whether adjuvant treatments in stage III cutaneous melanoma (CM) influenced patterns of recurrence. Patients with primary (<jats:italic>n<\/jats:italic>\u2009=\u20091033) or relapsed CM (<jats:italic>n<\/jats:italic>\u2009=\u2009350) who received adjuvant therapies with Nivolumab (N), Pembrolizumab (P), or Dabrafenib and Trametinib (D\u2009+\u2009T) were extracted from the prospective multicenter real\u2010world skin cancer registry ADOReg. Endpoints were progression\u2010free survival (PFS), distant metastasis\u2010free survival (DMFS), organ\u2010specific DMFS, and overall survival (OS). For primary cases, D\u2009+\u2009T indicated an improved PFS (1\u2010 and 2\u2010year PFS: 90.9%; 82.7%) as compared to P (81.0%, 73.9%; <jats:italic>p<\/jats:italic>\u2009=\u2009.0208), or N (83.8%, 75.2%; <jats:italic>p<\/jats:italic>\u2009=\u2009.0539). <jats:italic>BRAF<\/jats:italic>\u2010mutated(mut) CM demonstrated significantly lower PFS (<jats:italic>p<\/jats:italic>\u2009=\u2009.0022) and decreased DMFS (<jats:italic>p<\/jats:italic>\u2009=\u2009.0580) when treated with immune checkpoint inhibitor (ICI) instead of D\u2009+\u2009T. Besides, <jats:italic>NRAS<\/jats:italic>\u2010mut CM tended to perform worse than wt CM upon ICI (PFS: <jats:italic>p<\/jats:italic>\u2009=\u2009.1349; DMFS: <jats:italic>p<\/jats:italic>\u2009=\u2009.0540<jats:italic>)<\/jats:italic>. OS was similar between the groups. Relapsed cases showed decreased PFS, DMFS, and OS in comparison to primary (all: <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), without significant differences between the subgroups. Organ\u2010specific DMFS was significantly altered for primary cases with bone (<jats:italic>p<\/jats:italic>\u2009=\u2009.0367) or brain metastases (<jats:italic>p<\/jats:italic>\u2009=\u2009.0202). In relapsed CM, the frequency of liver (D\u2009+\u2009T: 1.5%; P: 12%; N: 9%) and LN metastases (D\u2009+\u2009T: 1.5%; P: 12%; N: 10.2%) was significantly lower with adjuvant D\u2009+\u2009T than ICI. <jats:italic>NRAS<\/jats:italic>\u2010mut CM showed increased recurrence in primary and relapsed cases. These data show that adjuvant D\u2009+\u2009T is superior to ICI in primary <jats:italic>BRAF<\/jats:italic>\u2010mut CM.<\/jats:p>","DOI":"10.1002\/ijc.35078","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T09:55:12Z","timestamp":1720432512000},"page":"1808-1823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of adjuvant therapies on organ\u2010specific recurrence of cutaneous melanoma: A multicenter study on 1383 patients of the prospective <scp>DeCOG<\/scp> registry <scp>ADOReg<\/scp>"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4677-6149","authenticated-orcid":false,"given":"Sebastian A.","family":"Wohlfeil","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim Heidelberg University, and Center of Excellence in Dermatology  Mannheim Germany"},{"name":"Section of Clinical and Molecular Dermatology, Medical Faculty Mannheim Heidelberg University  Mannheim Germany"},{"name":"Skin Cancer Unit German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"DKFZ Hector Cancer Institute at the University Medical Center Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Kranzmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim Heidelberg University, and Center of Excellence in Dermatology  Mannheim Germany"},{"name":"Skin Cancer Unit German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"DKFZ Hector Cancer Institute at the University Medical Center Mannheim  Mannheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Wei\u00df","sequence":"additional","affiliation":[{"name":"Department for Statistical Analysis, University Medical Center Mannheim, Faculty of Clinical Medicine Mannheim University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imke","family":"von Wasielewski","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Skin Cancer Center Hannover, Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai C.","family":"Klespe","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Skin Cancer Center Hannover, Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina C.","family":"K\u00e4hler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Cancer Center University Hospital Schleswig\u2010Holstein\u2014Campus Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weichenthal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Cancer Center University Hospital Schleswig\u2010Holstein\u2014Campus Kiel  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology University Hospital Essen and German Cancer Consortium (DKTK), Partner Site Essen\/D\u00fcsseldorf  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology University Hospital Essen and German Cancer Consortium (DKTK), Partner Site Essen\/D\u00fcsseldorf  Essen 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