{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:43:23Z","timestamp":1792212203490,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study is to report the long\u2010term timing and patterns of relapse for children enrolled in Children's Oncology Group AREN0534, a multicenter phase III clinical trial conducted from 2009 to 2015. Participants included children with bilateral Wilms tumor (BWT) or unilateral WT with genetic predisposition to develop BWT followed for up to 10\u2009years. Smoothed hazard (risk) functions for event\u2010free survival (EFS) were plotted so that the timing of events could be visualized, both overall and within pre\u2010specified groups. Two hundred and twenty\u2010two children (190 BWT and 32 unilateral WT with BWT predisposition) were followed for a median of 8.6\u2009years. Fifty events were reported, of which 48 were relapse\/progression. The overall 8\u2010year EFS was 75% (95% confidence interval: 69%\u201383%). The highest risk for an EFS event was immediately after diagnosis with a declining rate over 2\u2009years. A second peak of events was observed around 4\u2009years after diagnosis, and a small number of events were reported until the end of the follow\u2010up period. In subset analyses, later increases in risk were more commonly observed in patients with female sex, anaplastic histology, negative lymph nodes or margins, and favorable histology Wilms tumor patients with post\u2010chemotherapy intermediate risk. Among relapses that occurred after 2\u2009years, most were to the kidney. These patterns suggest that late events may be second primary tumors occurring more commonly in females, although more investigation is required. Clinicians may consider observation of patients with BWT beyond 4\u2009years from diagnosis.<\/jats:p>","DOI":"10.1002\/ijc.35080","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T05:40:45Z","timestamp":1720417245000},"page":"1824-1831","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term outcomes and patterns of relapse in patients with bilateral Wilms tumor or bilaterally predisposed unilateral Wilms tumor, a report from the <scp>COG AREN0534<\/scp> study"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6747-0355","authenticated-orcid":false,"given":"Andrew J.","family":"Murphy","sequence":"first","affiliation":[{"name":"St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Brzezinski","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Renfro","sequence":"additional","affiliation":[{"name":"Division of Biostatistics University of Southern California and Children's Oncology Group  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Tornwall","sequence":"additional","affiliation":[{"name":"Division of Biostatistics University of Southern California and Children's Oncology Group  Los Angeles California USA"},{"name":"Glaukos Corp.  San Clemente California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus M.","family":"Malek","sequence":"additional","affiliation":[{"name":"Children's Hospital of Pittsburgh University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Monroe Carell Jr. Children's Hospital at Vanderbilt Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Cost","sequence":"additional","affiliation":[{"name":"The Surgical Oncology Program at the Children's Hospital of Colorado University of Colorado  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Aldrink","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Nationwide Children's Hospital The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo L. P.","family":"Romao","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Dome","sequence":"additional","affiliation":[{"name":"Children National Hospital George Washington University School of Medicine and Health Sciences  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Davidoff","sequence":"additional","affiliation":[{"name":"St Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Treece","sequence":"additional","affiliation":[{"name":"Ann &amp; Robert H. Lurie Children's Hospital  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren N.","family":"Parsons","sequence":"additional","affiliation":[{"name":"Department of Pathology Children's Hospital of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Mullen","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital and Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Shamberger","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital and Dana Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold C.","family":"Paulino","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3253-1071","authenticated-orcid":false,"given":"Andrea C.","family":"Lo","sequence":"additional","affiliation":[{"name":"University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James I.","family":"Geller","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery, CS Mott Children's Hospital, University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002356"},{"key":"e_1_2_10_3_1","unstructured":"GrundyP BreslowN NorkoolP et al.National Wilms Tumor Study Five Statistical Report; 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