{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:59:43Z","timestamp":1789340383853,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"publisher","award":["940045"],"award-info":[{"award-number":["940045"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Head and neck squamous cell carcinomas (HNSCCs) are linked to tobacco smoking, opium use, and human papillomavirus (HPV) infection. However, little is known about the association of HPV infection with risk factors of HNSCCs, including opium and tobacco use. This cross\u2010sectional analysis of a national multi\u2010center case\u2013control study in Iran included 498 HNSCC cases and 242 controls. We investigated the association of opium and tobacco use with \u03b1\u2010 (<jats:italic>n<\/jats:italic>\u2009=\u200921), \u03b2\u2010 (<jats:italic>n<\/jats:italic>\u2009=\u200946), and \u03b3\u2010HPV (<jats:italic>n<\/jats:italic>\u2009=\u200952) types in saliva samples using type\u2010specific bead\u2010based multiplex genotyping assays (TS\u2010MPG). We found that \u03b1\u2010HPV positivity was significantly associated with tobacco smoking (OR\u2009=\u200910.35; 95% CI\u2009=\u20091.15, 93; <jats:italic>p<\/jats:italic>\u2009=\u2009.03), but not with opium use (OR\u2009=\u20091.06; 95% CI\u2009=\u20090.41, 2.76; <jats:italic>p<\/jats:italic>\u2009=\u2009.89). Additionally, tobacco smoking correlated with an elevated risk of \u03b2\u2010species 2 HPV infection (OR\u2009=\u20091.28; 95% CI\u2009=\u20091.04, 1.58; <jats:italic>p<\/jats:italic>\u2009=\u2009.020). Conversely, opium use showed a positive association with \u03b3\u2010species 12 HPV infection (OR\u2009=\u20095.67; 95% CI\u2009=\u20091.43, 22.44; <jats:italic>p<\/jats:italic>\u2009=\u2009.013). These findings indicate that tobacco and opium use may influence the risk of HPV infection in different ways depending on the HPV genus and species. Further studies are needed to replicate these findings in other populations.<\/jats:p>","DOI":"10.1002\/ijc.35086","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T08:28:21Z","timestamp":1721896101000},"page":"1544-1548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of opium use and tobacco smoking with \u03b1\u2010, \u03b2\u2010, and \u03b3\u2010human papillomavirus oral infection"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-8502","authenticated-orcid":false,"given":"Abbas","family":"Karimi","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Epigenomics and Mechanisms Branch, International Agency for Research on Cancer (IARC)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Mohebbi","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lombardi Comprehensive Cancer Center Georgetown University  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Mckay\u2010Chopin","sequence":"additional","affiliation":[{"name":"Epigenomics and Mechanisms Branch, International Agency for Research on Cancer (IARC)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Hadji","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Cancer Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Health Sciences Unit, Faculty of Social Sciences Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2155-1683","authenticated-orcid":false,"given":"Hamideh","family":"Rashidian","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Cancer Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Marzban","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Public Health Bushehr University of Medical Science  Bushehr Iran"},{"name":"Clinical Research Development Center, The Persian Gulf Martyrs Bushehr University of Medical Science  Bushehr Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Naghibzadeh\u2010Tahami","sequence":"additional","affiliation":[{"name":"Institute for Futures Studies in Health Kerman University of Medical Sciences  Kerman Iran"},{"name":"Department of Biostatistics and Epidemiology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahin","family":"Gholipour","sequence":"additional","affiliation":[{"name":"Metabolic Disorders Research Center Golestan University of Medical Sciences  Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Eslami","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Shafa Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farin","family":"Kamangar","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Computer, Mathematical Health Foresight and Innovation Research Center, and Natural Sciences Morgan State University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Tommasino","sequence":"additional","affiliation":[{"name":"Istituto Tumori Bari Giovanni Paolo II\u2014IRCCS  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Gheit","sequence":"additional","affiliation":[{"name":"Epigenomics and Mechanisms Branch, International Agency for Research on Cancer (IARC)  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0269-4945","authenticated-orcid":false,"given":"Kazem","family":"Zendehdel","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Cancer Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Cancer Biology Research Center, Cancer Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33289"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.5504"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-023-00969-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.13183"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3182641f1c"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e318286bb53"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223532"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00117-22"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.34172\/aim.2021.27"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pvr.2020.100199"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0591"},{"key":"e_1_2_10_13_1","volume-title":"IARC 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