{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:53:46Z","timestamp":1790916826842,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UM1CA173640"],"award-info":[{"award-number":["UM1CA173640"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["UM1CA182910"],"award-info":[{"award-number":["UM1CA182910"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The carcinogenicity of benzene was reevaluated by the International Agency for Research on Cancer in 2017, with the Working Group reaffirming positive yet inconclusive associations with non\u2010Hodgkin lymphoma (NHL). To extend our previous observation of a significant exposure\u2010response for cumulative occupational benzene exposure and NHL risk among Chinese women in a population\u2010based cohort in Shanghai, we extended follow\u2010up of this cohort and pooled the data with a similarly designed population\u2010based cohort of men in Shanghai. Cumulative exposure estimates were derived for 134,449 participants in the pooled analysis by combining ordinal job\u2010exposure matrix intensity ratings with quantitative benzene measurements from an inspection database of Shanghai factories. Associations between benzene exposure metrics and NHL (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009363 cases including multiple myeloma [MM]) were assessed using Cox proportional hazard models. Ever occupational exposure to benzene in the pooled population was associated with NHL risk (HR\u2009=\u20091.5, 95% CI\u2009=\u20091.2\u20132.0), and exposure\u2010response relationships were observed for increasing duration (\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>trend<\/jats:sub>\n                    \u2009=\u2009.003) and cumulative exposure (\n                    <jats:italic>p<\/jats:italic>\n                    <jats:sub>trend<\/jats:sub>\n                    \u2009=\u2009.003). Associations with ever exposure, duration, and cumulative exposure were similar for NHL with and without MM in the case definition, including lifetime cumulative exposures in the highest quartile (HR\u2009=\u20091.6, 95% CI\u2009=\u20091.1\u20132.4 with MM included; HR\u2009=\u20091.7, 95% CI\u2009=\u20091.1\u20132.7 with MM excluded). An elevated risk of the chronic lymphocytic leukemia subtype was suggested in the pooled analyses (HR for ever vs. never exposure\u2009=\u20092.3, 95% CI\u2009=\u20090.9\u20135.6). These observations provide additional support for a plausible association between occupational benzene exposure and risk of NHL.\n                  <\/jats:p>","DOI":"10.1002\/ijc.35095","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T09:39:44Z","timestamp":1725269984000},"page":"2159-2168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Occupational exposure to benzene and risk of non\u2010\n                    <scp>Hodgkin<\/scp>\n                    lymphoma in an extended follow\u2010up of two population\u2010based prospective cohorts of\n                    <scp>Chinese<\/scp>\n                    men and women"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-8597","authenticated-orcid":false,"given":"Bryan A.","family":"Bassig","sequence":"first","affiliation":[{"name":"Inova Schar Cancer Institute Inova Health System  Fairfax Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Ou","family":"Shu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa C.","family":"Friesen","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Institute for Risk Assessment Sciences Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1177-3108","authenticated-orcid":false,"given":"Mark P.","family":"Purdue","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu\u2010Tian","family":"Ji","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7006-5825","authenticated-orcid":false,"given":"Gong","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-2133","authenticated-orcid":false,"given":"Jason Y. Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Heart, Lung, and Blood Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Appel","sequence":"additional","affiliation":[{"name":"Information Management Services  Calverton Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Shanghai Cancer Institute Shanghai Jiaotong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center Vanderbilt University School of Medicine  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Rothman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lan","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"IARC Monographs on the Identification of Carcinogenic Hazards to Humans.Volume 120.2018Accessed February 25 2024.https:\/\/publications.iarc.fr\/Book-And-Report-Series\/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans\/Benzene-2018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327107083974"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.03.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15459620903249646"},{"issue":"3","key":"e_1_2_10_6_1","first-page":"192","article-title":"Occupational exposure to benzene in China","volume":"44","author":"Yin SN","year":"1987","journal-title":"Br J Ind Med"},{"key":"e_1_2_10_7_1","unstructured":"IARCMonographs on the evaluation of carcinogenic risks to humans. 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