{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:26:37Z","timestamp":1792081597044,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Denmark, alongside other Scandinavian countries, the United States, Canada, and the United Kingdom, has high prevalence of human papillomavirus (HPV). Our oropharyngeal squamous cell carcinoma (OPSCC) database includes all diagnosed cases in Eastern Denmark during a period of more than two decades. We investigated the incidence, survival, and recurrence of patients with OPSCC with combined p16\u2010 and HPV testing covering a consecutive 21\u2010year period. Age\u2010adjusted incidence rate (AAIR) per 100,000, survival models, and Cox proportional\u2010hazards model were employed. Two thousand eight hundred thirty\u2010four patients were included (57.5% HPV positive (HPV+)\/p16 positive (p16+), 33.7% HPV negative (HPV\u2010)\/p16 negative (p16\u2212), 4% HPV+\/p16\u2212, and 4.8% HPV\u2212\/p16+). The AAIR for all patients increased from 1.8 to 5.1 per 100,000 from 2000 to 2020 linked to an increasing AAIR of HPV+\/p16+ OPSCCs from 0.9 to 3.5 per 100,000 from 2000 to 2020. The AAIR for the HPV\u2212\/p16\u2212 OPSCCs decreased from 1.6 to 1.4 from 2017 to 2020. HPV+\/p16+ OPSCCs had a higher 5\u2010year overall survival (OS) of 79.2% compared to the other subgroups (HPV+\/p16\u2212 OS: 50.4%; HPV\u2212\/p16+ OS: 49.4%; HPV\u2212\/p16\u2212 OS: 35.1%). The AAIR of the total OPSCC group increased from year 2000 to 2020, driven by a rise in the HPV+\/p16+ group. A decreasing incidence rate was observed for the HPV\u2212\/p16\u2212 OPSCCs from 2017 to 2020. The OS for HPV+\/p16+ OPSCCs was significantly higher compared to all other HPV\/p16 subgroups. Therefore, we recommend testing for combined HPV and p16 status in patients with OPSCC when selecting patients for clinical trials, especially in case of de\u2010escalating\/escalating.<\/jats:p>","DOI":"10.1002\/ijc.35099","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T05:10:17Z","timestamp":1721193017000},"page":"2169-2179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Epidemiological trends and survival of oropharyngeal cancer in a high\n                    <scp>HPV<\/scp>\n                    \u2010prevalent area: A Danish population\u2010based study from 2000 to 2020"],"prefix":"10.1002","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6961-5642","authenticated-orcid":false,"given":"Benedicte Bitsch","family":"Lauritzen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias Waldemar","family":"Gr\u00f8nlund","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine Kronberg","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius Meldgaard","family":"Justesen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-8003","authenticated-orcid":false,"given":"Martin","family":"Garset\u2010Zamani","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda\u2010Louise Fenger","family":"Carlander","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1494-3352","authenticated-orcid":false,"given":"Jacob H\u00f8ygaard","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Kloch","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Pathology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie R\u00f8sland","family":"Rosen\u00f8rn","sequence":"additional","affiliation":[{"name":"Department of Pathology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe","family":"Friborg","sequence":"additional","affiliation":[{"name":"Department of Oncology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Knud Daugaard","family":"Bentzen","sequence":"additional","affiliation":[{"name":"Department of Oncology Copenhagen University Hospital \u2013 Herlev  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gr\u00f8nh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery and Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24339"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201016\u20100633"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.04.027"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2017.1390251"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2024.113983"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758\u20103284\u20102\u201015"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200104123441503"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622\u2010200105000\u201000009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx304"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.06.005"},{"key":"e_1_2_10_12_1","first-page":"185","article-title":"Head and neck cancers","author":"Swartz LK","year":"2024","journal-title":"J Natl Compr Canc Netw"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010018\u20100107\u20109"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.10.009"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.42"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13091692"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(23)00013\u2010X"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.10.015"},{"key":"e_1_2_10_19_1","unstructured":"Sundhedsstyrelsen.Pakkeforl\u00f8b for Hoved\u2010Og Halskraeft For Fagfolk.2020www.sst.dk"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_22_1","unstructured":"Sundhedsstyrelsen.Notat om Sundhedsstyrelsens alkoholudmeldinger. 2022; 1\u20135."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105\u2010024\u201001628\u20103"},{"key":"e_1_2_10_24_1","volume-title":"TNM Classification of Malignant Tumours","author":"Brierley JD","year":"2016"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25585"},{"key":"e_1_2_10_26_1","unstructured":"SSI.Vaccination mod human papilloma virus (HPV). Accessed March 3 2023.https:\/\/www.ssi.dk\/vaccinationer\/boernevaccination\/vaccination-mod-livmoderhalskraeft"},{"key":"e_1_2_10_27_1","unstructured":"Kr\u00e6ftens Bek\u00e6mpelse.Hvad er HPV\u2010vaccination?Accessed March 27 2024.https:\/\/www.cancer.dk\/forebyg-kraeft\/hpv-vaccination\/hvad-er-hpv-vaccination\/#Hvem_f\u00e5r_tilbudt_gratis_HPV-vaccination?"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2022.3762"},{"key":"e_1_2_10_29_1","unstructured":"Kr\u00e6ftens Bek\u00e6mpelse.Voksnes rygevaner. Accessed May 9 2023.https:\/\/www.cancer.dk\/forebyg\/undga\u2010roeg\u2010og\u2010rygning\/fakta\u2010om\u2010rygning\/voksnes\u2010rygevaner\/"},{"key":"e_1_2_10_30_1","unstructured":"Kr\u00e6ftens Bek\u00e6mpelse.Rygningens historie i Danmark. Accessed May 9 2023.https:\/\/www.cancer.dk\/skole\/viden-om-kraeft\/kan-man-undgaa-kraeft\/undgaa-rygning\/regler-om-rygning\/"},{"key":"e_1_2_10_31_1","unstructured":"Kr\u00e6ftens Bek\u00e6mpelse.Fald i kr\u00e6ftdiagnoser under corona ramte is\u00e6r tre store kr\u00e6ftsygdomme.2022Accessed September 28 2023.https:\/\/www.cancer.dk\/nyheder\/fald\u2010i\u2010kraeftdiagnoser\u2010under\u2010corona\u2010ramte\u2010isaer\u2010tre\u2010store\u2010kraeftsygdomme\/"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_10_33_1","unstructured":"UICC.TNM classification of malignant tumors \u2010 8th edition. Changes between the 7th and 8th editions. 2018."},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz010"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201023\u20101064"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29254"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.198"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.35099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.35099","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.35099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:44:24Z","timestamp":1771047864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.35099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12,15]]}},"alternative-id":["10.1002\/ijc.35099"],"URL":"https:\/\/doi.org\/10.1002\/ijc.35099","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]},"assertion":[{"value":"2024-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}