{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:18:43Z","timestamp":1773044323062,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["825741"],"award-info":[{"award-number":["825741"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LO 1928\/11\u20101"],"award-info":[{"award-number":["LO 1928\/11\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["424112940"],"award-info":[{"award-number":["424112940"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDAP 152220002 (CECAN)"],"award-info":[{"award-number":["FONDAP 152220002 (CECAN)"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gallbladder cancer (GBC) mortality in Chile is among the highest worldwide. In 2006, the Chilean government launched a programme guaranteeing access to gallbladder surgery (cholecystectomy) for patients aged 35\u201349\u2009years. We evaluated the impact of this programme on digestive cancer mortality. After conducting an interrupted time series analysis of hospitalisation and mortality data from 2002 to 2018 publicly available from the Chilean Department of Health Statistics and Information, we calculated the change in the proportion of individuals without gallbladder since 10\u2009years. We then estimated age, gender, region, and calendar\u2010year standardised mortality ratios (SMRs) as a function of the change in the proportion of individuals without gallbladder. The cholecystectomy rate increased by 45 operations per 100,000 persons per year (95%CI 19\u201372) after the introduction of the health programme. Each 1% increase in the proportion of individuals without gallbladder since 10\u2009years was associated with a 0.73% decrease in GBC mortality (95% CI \u22121.05% to \u22120.38%), but the negative correlation was limited to women, southern Chile and age over 60. We also found decreasing mortality rates for extrahepatic bile duct, liver, oesophageal and stomach cancer with increasing proportions of individuals without gallbladder. To conclude, 12\u2009years after its inception, the Chilean cholecystectomy programme has markedly and heterogeneously changed cholecystectomy rates. Results based on aggregate data indicate a negative correlation between the proportion of individuals without gallbladder and mortality due to gallbladder and other digestive cancers, which requires validation using individual\u2010level longitudinal data to reduce the potential impact of ecological bias.<\/jats:p>","DOI":"10.1002\/ijc.35138","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T14:24:50Z","timestamp":1723818290000},"page":"91-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cholecystectomy and digestive cancer in Chile: Complementary results from interrupted time series and aggregated data analyses"],"prefix":"10.1002","volume":"156","author":[{"given":"Constanza","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Statistical Genetics Research Group, Institute of Medical Biometry Heidelberg University  Heidelberg Germany"},{"name":"Center for Cancer Prevention and Control (CECAN)  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Garc\u00eda\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Estad\u00edstica Universidad Nacional de Educaci\u00f3n a Distancia (UNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Nervi","sequence":"additional","affiliation":[{"name":"Center for Cancer Prevention and Control (CECAN)  Santiago Chile"},{"name":"Departamento de Hematolog\u00eda y Oncolog\u00eda Escuela de Medicina Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar","family":"Munoz","sequence":"additional","affiliation":[{"name":"Hospital Regional de Talca  Talca Chile"},{"name":"Facultad de Medicina Universidad Cat\u00f3lica del Maule  Talca Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Morales","sequence":"additional","affiliation":[{"name":"Hospital Regional de Talca  Talca Chile"},{"name":"Facultad de Medicina Universidad Cat\u00f3lica del Maule  Talca Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Losada","sequence":"additional","affiliation":[{"name":"Universidad de la Frontera  Temuco Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Merino\u2010Pereira","sequence":"additional","affiliation":[{"name":"Departamento Manejo Integral del C\u00e1ncer y Otros Tumores, Subsecretaria de Salud P\u00fablica Ministerio de Salud de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Rothhammer","sequence":"additional","affiliation":[{"name":"Instituto de Alta Investigaci\u00f3n Tarapac\u00e1 University  Arica Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-5333","authenticated-orcid":false,"given":"Justo","family":"Lorenzo Bermejo","sequence":"additional","affiliation":[{"name":"Statistical Genetics Research Group, Institute of Medical Biometry Heidelberg University  Heidelberg Germany"},{"name":"Center for Cancer Prevention and Control (CECAN)  Santiago Chile"},{"name":"Laboratory of Biostatistics for Precision Oncology Institut de Canc\u00e9rologie Strasbourg Europe  Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"GLOBOCAN.2022."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872006000500004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0716-8640(13)70195-0"},{"key":"e_1_2_11_5_1","unstructured":"https:\/\/www.minsal.cl\/wp-content\/uploads\/2022\/01\/Informe-Mortalidad-Prematura-y-AVPP-por-C%C3%A1ncer-2009-2018.pdf"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02070.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21683"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.24"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2012.6.2.172"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/18.1.50"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03340170049027"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.51.6.349"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540613"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840170102"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006756"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31537"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt322"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.03.227"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061484"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872019000700860"},{"key":"e_1_2_11_21_1","first-page":"348","article-title":"Interrupted time series regression for the evaluation of public health interventions: a tutorial","volume":"46","author":"Bernal JL","year":"2017","journal-title":"Int J Epidemiol"},{"key":"e_1_2_11_22_1","first-page":"1414","article-title":"Corrigendum to: interrupted time series regression for the evaluation of public health interventions: a tutorial","volume":"49","author":"Bernal JL","year":"2020","journal-title":"Int J Epidemiol"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.02.007"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2019.100474"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwae027"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365528709089770"},{"key":"e_1_2_11_27_1","first-page":"45","article-title":"Bile reflux to the stomach and gastritis before and after cholecystectomy","volume":"520","author":"Eriksson L","year":"1984","journal-title":"Acta Chir Scand Suppl"},{"key":"e_1_2_11_28_1","first-page":"153","article-title":"Bile reflux after cholecystectomy","volume":"67","author":"Kalima T","year":"1981","journal-title":"Scand J Gastroenterol Suppl"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12986"},{"key":"e_1_2_11_30_1","first-page":"840","article-title":"Associations of cholecystectomy with the risk of colorectal cancer: a mendelian randomization study","volume":"136","author":"Chen L","year":"2023","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-22-2049"},{"key":"e_1_2_11_32_1","volume-title":"Physiology","author":"Dave HD","year":"2024"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2021011"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2010.06.003"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2020.25.3.164"},{"key":"e_1_2_11_36_1","first-page":"579","article-title":"Cancer mortality among patients undergoing cholecystectomy for benign biliary diseases","volume":"77","author":"Ichimiya H","year":"1986","journal-title":"Jpn J Cancer Res"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2011.03.001"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000515545"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.35138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T12:21:27Z","timestamp":1731500487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.35138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/ijc.35138"],"URL":"https:\/\/doi.org\/10.1002\/ijc.35138","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,16]]},"assertion":[{"value":"2024-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}