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We investigated the optimal therapy for hmoNPC. 160 patients with hmoNPC treated in Sun Yat\u2010sen University Cancer Center between 2010 and 2021 were retrospectively recruited. A total of 56 patients were classified into the local therapy (LT) cohort, 23 into the systemic therapy (ST) cohort and 81 into the combination therapy (LT\u2009+\u2009ST) cohort. The median PFS was 7.9\u2009months (95% confidence interval [CI]: 4.1\u201311.9\u2009months) in the LT cohort, 15.5\u2009months (95% CI: 10.5\u201332.3\u2009months) in the ST cohort, and 31.3\u2009months (95% CI: 20.3 to NA months) in the LT\u2009+\u2009ST cohort. The median OS was 41.1\u2009months (95% CI: 30.0\u201354.0\u2009months) in the LT cohort, 50.4\u2009months (95% CI: 41.5 to NA months) in the ST cohort and not reached (NR) (95% CI: 77.3 to NA months) in the LT\u2009+\u2009ST cohort. Cox analysis was used to construct nomograms to predict patient outcomes. Among patients with no evidence of disease status after LT, the prognosis was significantly better in the LT\u2009+\u2009ST cohort than LT cohort (median PFS: NR [95% CI: 29.0 to NA months] vs. 20.0\u2009months [95% CI: 10.4 to NA months]). More survival benefits were achieved with platinum\u2010based chemotherapy than oral monotherapy (median PFS: NR [95% CI: 21.7 to NA months] vs. 17.2\u2009months [95% CI: 10.2 to NA months]). Fewer postoperative early progression events were observed in neoadjuvant chemotherapy cohort than in adjuvant chemotherapy cohort (2.78% vs. 18.81%, <jats:italic>P<\/jats:italic>\u2009=\u2009.013). In conclusion, combining neoadjuvant platinum\u2010based chemotherapy and local therapy was the best strategy for patients with hmoNPC.<\/jats:p>","DOI":"10.1002\/ijc.35139","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T04:16:51Z","timestamp":1724732211000},"page":"174-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Optimal therapeutic strategies for hepatic metachronous oligometastatic nasopharyngeal carcinoma: Insights from a retrospective study"],"prefix":"10.1002","volume":"156","author":[{"given":"Haoyang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejiang","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of 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Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nasopharyngeal Carcinoma, Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation 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