{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:39:14Z","timestamp":1773419954954,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cancer patients are at a higher risk to develop severe COVID\u201019 symptoms after SARS\u2010CoV\u20102 infection compared to the general population and regularly show an impaired immune response to SARS\u2010CoV\u20102 vaccination. In our oncological center, 357 patients with hematological and oncological diseases were monitored for neutralizing antibodies from October 2021 over 12\u2009months. All patients had received three anti\u2010SARS\u2010CoV\u20102 vaccinations with an mRNA\u2014(Comirnaty\/BionTech or Spikevax\/Moderna) or a vector vaccine (Vakzevria\/AstraZeneca or JCOVDEN\/Johnson&amp;Johnson). Neutralizing anti\u2010SARS\u2010CoV\u20102 IgG antibodies in the patients' sera were detected within 3\u2009months before, 3\u201310\u2009weeks and 5\u20137\u2009months after the booster vaccination (third vaccination). 112 patients developed a breakthrough SARS\u2010CoV\u20102 infection during the observation period. High anti\u2010SARS\u2010Cov\u20102 antibody levels before infection significantly protected against symptomatic Covid\u201019 disease (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.003). The median antibody titer in patients with asymptomatic Covid\u201019 disease was 2080 BAU\/ml (binding antibody units per Milliliter) and 765 BAU\/ml in symptomatic patients. 98% of the solid tumor patients reached seroconversion after the booster vaccination in comparison to 79% of the hematological patients. High antibody titers of &gt;2080 BAU\/ml after the booster vaccination were detected in 61% of the oncological and 34.8% of the hematological patients. 7\u201310\u2009months after the booster vaccination, the anti\u2010SARS\u2010CoV\u20102 antibody titer declined to an average of 849 BAU\/ml. Considering the heterogenous humoral immune response of cancer patients observed in this study, an individual vaccination strategy based on regular measurement of anti\u2010SARS\u2010CoV\u20102 antibody levels should be considered in contrast to fixed vaccination intervals.\n                  <\/jats:p>","DOI":"10.1002\/ijc.35162","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T11:09:40Z","timestamp":1725275380000},"page":"2141-2148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Humoral immune response as an indicator for protection against Covid\u201019 after anti\u2010SARS\u2010COV2\u2010booster vaccination in hematological and oncological patients"],"prefix":"10.1002","volume":"155","author":[{"given":"Dieter","family":"Mainka","sequence":"first","affiliation":[{"name":"Oncological Therapy Center MVZ West  Cologne 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