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Our objective was to identify and characterize childhood acute lymphoblastic leukemia (ALL) survivors with possible aLQTS using maximal exercise testing. In this cross\u2010sectional study with exploratory analysis, a total of 250 childhood ALL survivors were evaluated for abnormal QT interval prolongation using the McMaster cycle exercise test. A total of 198 survivors (102 males; 96 females), having reached their  peak (mean 32.1\u2009\u00b1\u20098.4\u2009mL\/kg\/min; range 15.5\u201357.8\u2009mL\/kg\/min), were included in our analyses. Two survivors were excluded for possible congenital LQTS. QT intervals were corrected for heart rate using the Bazett, Fridericia, and Rautaharju formulas at rest (supine, sitting, and standing positions), at the end of each stage of the CPET, and at 1, 3, and 5\u2009minutes into the recovery period. The corrected QT (QTc) of borderline (<jats:italic>n<\/jats:italic>\u2009=\u200937) and long QT survivors (<jats:italic>n<\/jats:italic>\u2009=\u200920) was significantly longer than normal survivors (<jats:italic>n<\/jats:italic>\u2009=\u2009141) at rest, exercise, and recovery. Out of 57 survivors presenting an abnormal QTc prolongation, 40 survivors (70%) showed no QT interval anomalies at rest but developed various anomalies during exercise. No significant differences were found between the groups for any of the measured clinical characteristics or cardiac parameters. The standardization of exercise testing in the regular follow\u2010up of oncology patients is necessary for appropriate cardiac prevention and surveillance to enhance the health and quality of life of the ever\u2010increasing number of cancer survivors.<\/jats:p>","DOI":"10.1002\/ijc.35168","type":"journal-article","created":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T12:08:30Z","timestamp":1725797310000},"page":"403-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uncovering possible silent acquired long <scp>QT<\/scp> syndrome using exercise stress testing in long\u2010term pediatric acute lymphoblastic leukemia survivors"],"prefix":"10.1002","volume":"156","author":[{"given":"Audrey","family":"Harvey","sequence":"first","affiliation":[{"name":"Faculty of Medicine, School of Kinesiology and Physical Activity Sciences University of Montreal  Montreal Quebec Canada"},{"name":"Sainte\u2010Justine 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