{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:55:37Z","timestamp":1790654137692,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gall bladder cancer (GBC) is common among the socioeconomically deprived populations of certain geographical regions. Aflatoxin is a genotoxic hepatocarcinogen, which is recognized to have a role in the pathogenesis of hepatocellular carcinoma. However, the role of aflatoxin in the pathogenesis of GBC is largely unknown. We determined serum AFB1\u2010Lys albumin adduct (AAA) levels as a marker of aflatoxin exposure in the patients with GBC and compared to those without GBC. The relationship of AAA levels to cytogenetic (TP53mutation&amp;HER2\/neu amplification) and radiological characteristics of the tumor was assessed. We included GBC cases (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200951) and non\u2010GBC controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009100). Mean serum AAA levels were higher in the GBC group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200951) than those without GBC (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009100) (26.1\u2009\u00b1\u200912.2 vs. 13.1\u2009\u00b1\u200911.9\u2009ng\/mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001). HER2\/neu expression was associated with higher AAA levels compared to those with equivocal or negative expression (43.9\u2009\u00b1\u20093 vs. 28.6\u2009\u00b1\u200910 vs. 19.3\u2009\u00b1\u20097\u2009ng\/mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001). Older age (age &gt;50\u2009years) (odds ratio [OR]\u2009=\u20093.2 [CI: 1.3\u20138.2];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.013), positive\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    serology (OR\u2009=\u20095.1 [CI: 1.4\u201317.8];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.012), presence of GS (OR\u2009=\u20095 [CI: 1.5\u201316.9];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.009) and detectable AAA levels (OR\u2009=\u20096.8 [CI: 1.3\u201335.7];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.024) were independent risk factors for the presence of the GBC among all study subjects. Among patients harboring GS, older age (age &gt;50\u2009years) (OR\u2009=\u20094.5 [CI: 1.3\u201314.9];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.015), female gender (OR\u2009=\u20093.8 [CI: 1.2\u201312.5];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.027), presence of multiple GS (OR\u2009=\u200921.9 [CI: 4.8\u2013100.4];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001) and high serum AAA levels (OR\u2009=\u20095.3 [CI: 1.6\u201317.3];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.006) were independent risk factors for the presence of the GBC. Elderly age &gt;50\u2009years (OR\u2009=\u20092.6 [CI: 1.3\u20135.2];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.010) and frequent peanut consumption (OR\u2009=\u20092.3 [CI: 1.1\u20134.9];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.030) were independent risk factors for high serum AAA levels. The current study has implications for the prevention of GBC through the reduction of dietary aflatoxin exposure.\n                  <\/jats:p>","DOI":"10.1002\/ijc.35171","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T07:35:06Z","timestamp":1725608106000},"page":"322-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Aflatoxin exposure is associated with an increased risk of gallbladder cancer"],"prefix":"10.1002","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4430-744X","authenticated-orcid":false,"given":"Amit","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Gastroenterology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parikshaa","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cytology &amp; Gynecological Pathology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol N.","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan K.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Hooda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thakur Deen","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Surgery PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lileswar","family":"Kaman","sequence":"additional","affiliation":[{"name":"Department of Surgery PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarnail Singh","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and School of Public Health PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Kishan","family":"Sudini","sequence":"additional","affiliation":[{"name":"International Crops Research Institute for the Semi\u2010Arid Tropics Patancheru  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-091X","authenticated-orcid":false,"given":"Radhika","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Cytology &amp; Gynecological Pathology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-3557","authenticated-orcid":false,"given":"Usha","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology PGIMER  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43055-020-00386-w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2019.08.03"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27777"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21683"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJB2016.15305"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12550-021-00431-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i10.1508"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins11010027"},{"key":"e_1_2_9_10_1","first-page":"63","volume-title":"Mycotoxins\u2010Induced Oxidative Stress and Disease","author":"Omar HJM","year":"2013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2015.12.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2006.00320.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61157-1"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(03)00385-9"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"29","article-title":"Role of EGFR and HER\u20102\/NEU expression in gall bladder carcinoma (GBC)","volume":"13","author":"Das C","year":"2021","journal-title":"J Lab Phys"},{"issue":"2","key":"e_1_2_9_16_1","first-page":"42","article-title":"Overexpression of the HER2\/neu gene: a new therapeutic possibility for patients with advanced gallbladder cancer","volume":"7","author":"Roa I","year":"2014","journal-title":"Gastrointest Cancer Res"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1169"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.4559"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.005"},{"key":"e_1_2_9_20_1","first-page":"554","article-title":"Gallbladder reporting and data system (GB\u2010RADS) for risk stratification of gallbladder wall thickening on ultrasonography: an international expert consensus. Abdominal","volume":"47","author":"Gupta P","year":"2022","journal-title":"Radiology"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.56501\/intjcommunitydent.v10i1.26"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJPM.IJPM_664_19"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqw206"},{"issue":"5","key":"e_1_2_9_24_1","article-title":"Mutant phenotype p53 immunohistochemical expression is associated with poor prognostic parameters and disease\u2010free survival in triple\u2010negative metaplastic breast carcinoma","volume":"13","author":"Hashmi AA","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/joc.joc_224_21"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240565"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911856"},{"issue":"6","key":"e_1_2_9_28_1","first-page":"617","article-title":"Aflatoxin B1, and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a meta\u2010analysis of existing studies","volume":"10","author":"Stern MC","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160508"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.35171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T06:44:49Z","timestamp":1748933089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.35171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,15]]}},"alternative-id":["10.1002\/ijc.35171"],"URL":"https:\/\/doi.org\/10.1002\/ijc.35171","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]},"assertion":[{"value":"2024-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}