{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:59:10Z","timestamp":1792202350625,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["ANRS 12375"],"award-info":[{"award-number":["ANRS 12375"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The WHO recommends the use of human papillomavirus (HPV) testing for primary cervical cancer (CC) screening because of its high sensitivity. However, triage is desirable to correctly identify HPV+ women who have high\u2010grade lesions (CIN2+) and require treatment. The ANRS\u201012375 study was conducted in C\u00f4te d'Ivoire, Burkina Faso and Cambodia to assess the performance, feasibility and benefits of different triage options for detecting CIN2+ lesions: partial (HPV16 and HPV16\/18\/45) and extended genotyping, visual inspection (VIA) alone and VIA combined with partial genotyping. VIA was performed by gynecologists. The sensitivity, specificity, and diagnostic likelihood ratio (DLR) of each triage option for detecting CIN2+ lesions with histology as a reference standard were calculated. Of the 2253 women living with HIV (WLHIV) included, 932 (41%) were HPV+. A CIN2+ lesion was identified in 105 (13%) of the 777 participants with histopathology results. The sensitivity of VIA as a triage test for CIN2+ patients was 89%, while that for extended genotyping was 89%, that for HPV16\/18\/45 partial genotyping was 51%, and that for HPV16 partial genotyping was 36%. The specificities for these tests were 45%, 29%, 72%., and 85%, respectively. Combining VIA and\/or partial genotyping positivity slightly increased the sensitivity (94%) at the cost of lower specificity (28%). There was significant intersite heterogeneity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.04). Among the three triage tests with a sensitivity \u226585%, the VIA had the highest specificity and positive likelihood ratio (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001). VIA and extended genotyping, whether independent or combined, are good triage options with high sensitivity for identifying WLHIV needing treatment for CIN2+.\n                  <\/jats:p>","DOI":"10.1002\/ijc.35190","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T11:16:34Z","timestamp":1727262994000},"page":"598-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Performance of visual inspection, partial genotyping, and their combination for the triage of women living with HIV who are screen positive for human papillomavirus: Results from the AIMA\u2010CC ANRS 12375 multicentric screening study"],"prefix":"10.1002","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-6057","authenticated-orcid":false,"given":"Pierre","family":"Debeaudrap","sequence":"first","affiliation":[{"name":"Centre Population and Development (CEPED), Inserm ERL 1244 French National 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Hospital  Eaubonne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Sothea","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University of Health Sciences  Phnom Penh Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Vassilakos","sequence":"additional","affiliation":[{"name":"Geneva Foundation for Medical Education and Research  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armel","family":"Poda","sequence":"additional","affiliation":[{"name":"Adult HIV Day Care Centre Sour\u00f4 Sanou University Teaching Hospital  Bobo\u2010Dioulasso Burkina Faso"},{"name":"Institut Sup\u00e9rieur des Sciences de la Sant\u00e9 NAZi BONI University  Bobo\u2010Dioulasso Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn Kasil\u00e9","family":"Poda","sequence":"additional","affiliation":[{"name":"Gynaecologic Department Yopougon 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