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However, evidence regarding the optimal choice of multimodal treatment approaches is lacking, in particular with respect to the integration of immunotherapy. This real\u2010world study identified 218 patients with OMD NSCLC (2004\u20132023, prespecified criteria: \u22645 metastases in \u22642 organ systems) from three major German comprehensive cancer centers. Most patients had one (72.5%) or two (17.4%) metastatic lesions in a single (89.9%) organ system. Overall survival (OS) was significantly longer with a single metastatic lesion (HR 0.54, <jats:italic>p<\/jats:italic>\u2009=\u2009.003), and female gender (HR 0.4, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Median OS of the full cohort was 27.8\u2009months, with 29% survival at 5\u2009years. Patients who had completed LAT to all NSCLC sites, typically excluding patients with early progression, had a median OS of 34.4\u2009months (37.7% 5\u2010year OS rate) with a median recurrence\u2010free survival (RFS) of 10.9\u2009months (13.3% at 5\u2009years). In those patients, systemic treatment as part of first\u2010line therapy was associated with doubling of RFS (12.3 vs. 6.4\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Despite limited follow\u2010up of patients receiving chemo\u2010immunotherapy (EU approval 2018\/2019), RFS was greatly improved by adding checkpoint inhibitors to chemotherapy (HR 0.44, <jats:italic>p<\/jats:italic>\u2009=\u2009.008, 2\u2010year RFS 51.4% vs. 15.1%). In conclusion, patients with OMD NSCLC benefitted from multimodality approaches integrating systemic therapy and local ablation of all cancer sites. A substantial proportion of patients achieved extended OS, suggesting a potential for cure that can be further augmented with the addition of immunotherapy.<\/jats:p>","DOI":"10.1002\/ijc.35199","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T15:10:07Z","timestamp":1727277007000},"page":"776-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Oligometastatic non\u2010small cell lung cancer: Impact of local and contemporary systemic treatment approaches on clinical outcome"],"prefix":"10.1002","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9698-9559","authenticated-orcid":false,"given":"Marcel","family":"Wiesweg","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, West German Cancer Center, University Hospital Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"Division of Thoracic Oncology, West German Cancer Center, 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