{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:19:13Z","timestamp":1788279553568,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8221\/A29017"],"award-info":[{"award-number":["C8221\/A29017"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8221\/A30904"],"award-info":[{"award-number":["C8221\/A30904"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Measuring pre\u2010diagnostic blood metabolites may help identify novel risk factors for prostate cancer. Using data from 4387 matched case\u2013control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the associations of 148 individual metabolites and three previously defined metabolite patterns with prostate cancer risk. Metabolites were measured by liquid chromatography\u2010mass spectrometry. Multivariable\u2010adjusted conditional logistic regression was used to estimate the odds ratio per standard deviation increase in log metabolite concentration and metabolite patterns (OR1SD) for prostate cancer overall, and for advanced, high\u2010grade, aggressive. We corrected for multiple testing using the Benjamini\u2013Hochberg method. Overall, there were no associations between specific metabolites or metabolite patterns and overall, aggressive, or high\u2010grade prostate cancer that passed the multiple testing threshold (\n                    <jats:italic>padj<\/jats:italic>\n                    &lt;0.05). Six phosphatidylcholines (PCs) were inversely associated with advanced prostate cancer diagnosed at or within 10\u2009years of blood collection. metabolite patterns 1 (64 PCs and three hydroxysphingomyelins) and 2 (two acylcarnitines, glutamate, ornithine, and taurine) were also inversely associated with advanced prostate cancer; when stratified by follow\u2010up time, these associations were observed for diagnoses at or within 10\u2009years of recruitment (OR\n                    <jats:sub>1SD<\/jats:sub>\n                    0.80, 95% CI 0.66\u20130.96 and 0.76, 0.59\u20130.97, respectively) but were weaker after longer follow\u2010up (0.95, 0.82\u20131.10 and 0.85, 0.67\u20131.06). Pattern 3 (8 lyso PCs) was associated with prostate cancer death (0.82, 0.68\u20130.98). Our results suggest that the plasma metabolite profile changes in response to the presence of prostate cancer up to a decade before detection of advanced\u2010stage disease.\n                  <\/jats:p>","DOI":"10.1002\/ijc.35208","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T13:11:05Z","timestamp":1728393065000},"page":"943-952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case\u2013control sets from the European Prospective Investigation into Cancer and Nutrition"],"prefix":"10.1002","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-5929","authenticated-orcid":false,"given":"Zoe S.","family":"Grenville","sequence":"first","affiliation":[{"name":"Cancer Epidemiology Unit, Oxford Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urwah","family":"Noor","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Oxford Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch International Agency for Research on Cancer, World Health Organization  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Gunter","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch International Agency for Research on Cancer, World Health Organization  Lyon France"},{"name":"Department of Epidemiology and Biostatistics School of Public Health, Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch International Agency for Research on Cancer, World Health Organization  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Agnoli","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumouri  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Amiano","sequence":"additional","affiliation":[{"name":"CIBER of Epidemiology and Public Health (CIBERESP)  Madrid Spain"},{"name":"Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa  San Sebastian Spain"},{"name":"BioGipuzkoa (BioDonostia) Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2597-2060","authenticated-orcid":false,"given":"Alberto","family":"Catalano","sequence":"additional","affiliation":[{"name":"Centre for Biostatistics, Epidemiology, and Public Health, Department of Clinical and Biological Sciences University of Turin  Orbassano Italy"},{"name":"Department of Translational Medicine University of Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Chirlaque","sequence":"additional","affiliation":[{"name":"CIBER of Epidemiology and Public Health (CIBERESP)  Madrid Spain"},{"name":"Department of Epidemiology Regional Health Council, IMIB\u2010Arrixaca, Murcia University  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-4436","authenticated-orcid":false,"given":"Sofia","family":"Christakoudi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics White City Campus, Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Guevara","sequence":"additional","affiliation":[{"name":"Instituto de Salud P\u00fablica y Laboral de Navarra  Pamplona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"},{"name":"Navarra Institute for Health Research (IdiSNA)  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Johansson","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch International Agency for Research on Cancer, World Health Organization  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Kaaks","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology German Cancer research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Katzke","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology German Cancer research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Masala","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Institute for Cancer Research, Prevention and Clinical Network (ISPRO)  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Olsen","sequence":"additional","affiliation":[{"name":"The Danish Cancer Institute  Copenhagen Denmark"},{"name":"Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Papier","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Oxford Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Jose","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"},{"name":"Escuela Andaluza de Salud P\u00fablica (EASP)  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA  Granada Spain"},{"name":"Department of Preventive Medicine and Public Health University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias B.","family":"Schulze","sequence":"additional","affiliation":[{"name":"Department of Molecular Epidemiology German Institute of Human Nutrition Potsdam\u2010Rehbruecke  Nuthetal Germany"},{"name":"Institute of Nutritional Science, University of Potsdam  Nuthetal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tj\u00f8nneland","sequence":"additional","affiliation":[{"name":"The Danish Cancer Institute  Copenhagen Denmark"},{"name":"Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy Y. N.","family":"Tong","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Oxford Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Tumino","sequence":"additional","affiliation":[{"name":"Hyblean Association for Epidemiology Research, AIRE ONLUS  Ragusa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2237-0128","authenticated-orcid":false,"given":"Elisabete","family":"Weiderpass","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer, World Health Organization  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-6804","authenticated-orcid":false,"given":"Raul","family":"Zamora\u2010Ros","sequence":"additional","affiliation":[{"name":"Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Key","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Oxford Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Smith\u2010Byrne","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Oxford Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7733-8750","authenticated-orcid":false,"given":"Julie A.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Oxford Population Health University of Oxford  Oxford UK"},{"name":"Department of Clinical Epidemiology, Department of Clinical Medicine Aarhus University and Aarhus, University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth C.","family":"Travis","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Oxford Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay 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