{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:23:48Z","timestamp":1787761428537,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Burkitt lymphoma (BL) has a tight association with Epstein\u2013Barr virus (EBV), especially in sub\u2010Saharan Africa. While the relationship between BL and EBV is well documented, the relationship between the anti\u2010EBV adaptive immune response, particularly in sub\u2010Saharan African cases, and disease course, has not been substantially investigated. An analysis of T\u2010cell receptor (TCR) complementarity determining region\u20103 (CDR3) sequences, reported here, from EBV\u2010positive, Ugandan BL tumor samples revealed a correlation between the presence of anti\u2010EBV CDR3s and improved overall survival probabilities. Furthermore, chemical complementarity assessments demonstrated higher complementarity for TCR CDR3s and EBV epitopes in the cases where there had been a detection of the anti\u2010EBV CDR3 AA sequence matches in the BL tumor samples. Overall, the results reported here raise the question of whether EBV targeted immunotherapy would lead to better BL outcomes?<\/jats:p>","DOI":"10.1002\/ijc.35212","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T12:59:24Z","timestamp":1728392364000},"page":"652-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Detection of anti\u2010\n                    <scp>EBV TCR CDR3s<\/scp>\n                    associated with better outcomes for\n                    <scp>EBV<\/scp>\n                    \u2010positive, Ugandan cases of Burkitt lymphoma"],"prefix":"10.1002","volume":"156","author":[{"given":"Rahul","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha I.","family":"Huda","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijit","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Chobrutskiy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Oregon Health and Science University Hospital  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris I.","family":"Chobrutskiy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Oregon Health and Science University Hospital  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline C.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandini","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1664-0996","authenticated-orcid":false,"given":"George","family":"Blanck","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine, University of South Florida  Tampa Florida USA"},{"name":"Department of Immunology H. 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