{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:06:21Z","timestamp":1768885581017,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173212"],"award-info":[{"award-number":["82173212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772531"],"award-info":[{"award-number":["81772531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum hepatitis B core\u2010related antigen (HBcrAg) is considered a surrogate marker of the amount and activity of intrahepatic covalently closed circular DNA. This study aimed to explore the prognostic value of HBcrAg on patients with hepatitis B virus (HBV)\u2010related hepatocellular carcinoma (HCC) after curative hepatectomy undergoing antiviral therapy (AVT). Data of 949 consecutive patients with HBV\u2010related HCC undergoing curative resection between 2010 and 2013 were reviewed. Serum HBcrAg levels were measured at surgery (baseline) for all patients and at the time of 2\u2009years postoperatively (on\u2010treatment) for those without recurrence. Primary endpoint was tumor recurrence. High HBcrAg levels are associated with malignant phenotypes. HBcrAg independently affected both recurrence and overall survival (OS) in patients with negative hepatitis B e antigen (HBeAg\u2212, <jats:italic>p<\/jats:italic>\u2009=\u2009.007 and <jats:italic>p<\/jats:italic>\u2009=\u2009.042, respectively) but not in their positive HBeAg (HBeAg+) counterparts (<jats:italic>p<\/jats:italic>\u2009=\u2009.100 and <jats:italic>p<\/jats:italic>\u2009=\u2009.075, respectively). Patients with high baseline HBcrAg had higher late, but not early recurrence rates than those with low baseline HBcrAg levels, regardless of HBeAg status (HBeAg+: <jats:italic>p<\/jats:italic>\u2009=\u2009.307 for early, <jats:italic>p<\/jats:italic>\u2009=\u2009.001 for late; HBeAg\u2212: <jats:italic>p<\/jats:italic>\u2009=\u2009.937 for early, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 for late). On\u2010treatment HBcrAg independently affected late recurrence in patients stratified by both cirrhosis and HBeAg (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 for all). The predictive power of HBcrAg kinetics for late recurrence was better than that of the baseline and on\u2010treatment HBcrAg. High HBcrAg levels during long\u2010term AVT are associated with late recurrence of HCC after hepatectomy. Combining baseline and on\u2010treatment HBcrAg might be valuable in identifying patients at a high risk of relapse and stratifying surveillance strategies postoperatively.<\/jats:p>","DOI":"10.1002\/ijc.35224","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T10:53:38Z","timestamp":1729853618000},"page":"1293-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>HBcrAg<\/scp> is associated with prognosis of hepatitis B virus\u2010related hepatocellular carcinoma in patients after hepatectomy undergoing antiviral therapy"],"prefix":"10.1002","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9206-8261","authenticated-orcid":false,"given":"Jian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hepatic Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"},{"name":"Department of Biliary Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbo","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery Tenth People's Hospital of Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery People's Hospital of Yang Zhong  Zhenjiang Jiangsu Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xintong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Biliary Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biliary Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longjiu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Biliary Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeye","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanming","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery People's Hospital of Shaoxing  Shaoxing Zhejiang Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Biliary Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biliary Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery, the Eastern Hepatobiliary Surgery Hospital Naval Medical University  Shanghai China"},{"name":"Department of Hepatobiliary and Pancreatic Surgery Tenth People's Hospital of Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1713263"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000466"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.07.009"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000858"},{"key":"e_1_2_11_6_1","first-page":"370","article-title":"EASL 2017 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