{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:14:22Z","timestamp":1792628062482,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Radiotherapy for breast cancer has been associated with an increased risk of secondary malignancies, including primary lung cancer. Whether this association varies by histological subtype of lung cancer remains unknown. Based on the data from 12 Surveillance, Epidemiology, and End Results registries, we examined the association between radiotherapy receipt and the risk of subtype\u2010specific subsequent primary lung cancer (SPLC) among female first primary breast cancer cases diagnosed between ages 20 and 84 from 1992 to 2020. More than half (53%) of the 550,007 breast cancer survivors identified had undergone radiotherapy as part of their initial breast cancer treatment. Over an average follow\u2010up of 9.7\u2009years, 8014 survivors developed SPLCs. For small\u2010cell carcinoma, the standardized incidence ratio (SIR) compared with the general population was higher for survivors who received radiotherapy (SIR\u2009=\u20091.15, 95% confidence interval [CI]\u2009=\u20091.06\u20131.25) but similar for those who did not receive radiotherapy (SIR\u2009=\u20091.00, 95% CI\u2009=\u20090.91\u20131.09), with the difference in SIRs being statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u2009.003). Similar associations were found for squamous cell carcinoma (SIR<jats:sub>yes<\/jats:sub>\u2009=\u20091.16, 95% CI\u2009=\u20091.08\u20131.24 vs. SIR<jats:sub>no\/unknown<\/jats:sub>\u2009=\u20091.06, 95% CI\u2009=\u20090.98\u20131.15; <jats:italic>p<\/jats:italic>\u2009=\u2009.07). The increased risks were confined to ipsilateral SPLC, with the greatest SIRs for small\u2010cell carcinoma occurring 5\u201310\u2009years since breast cancer diagnosis (SIR\u2009=\u20091.83, 95% CI\u2009=\u20091.53\u20132.19) and for squamous cell carcinoma with a latency of 10\u2009years or more (SIR\u2009=\u20091.64, 95% CI\u2009=\u20091.42\u20131.88). In contrast, the risk of developing adenocarcinoma did not vary by radiotherapy receipt (SIR<jats:sub>yes<\/jats:sub>\u2009=\u20091.23, 95% CI\u2009=\u20091.18\u20131.28 vs. SIR<jats:sub>no\/unknown<\/jats:sub>\u2009=\u20091.17, 95% CI\u2009=\u20091.12\u20131.22; <jats:italic>p<\/jats:italic>\u2009=\u2009.18), indicating additional risk factors in play. The findings suggest a distinct carcinogenic pathway of radiation\u2010induced lung cancer across histological subtypes and may inform risk\u2010stratified surveillance guidelines for SPLC.<\/jats:p>","DOI":"10.1002\/ijc.35257","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T12:20:11Z","timestamp":1731500411000},"page":"1114-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of radiotherapy receipt with lung cancer risk by histological subtype among breast cancer survivors in the United States"],"prefix":"10.1002","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9457-0950","authenticated-orcid":false,"given":"Chenxi","family":"Jiang","sequence":"first","affiliation":[{"name":"Surveillance &amp; Health Equity Science, American Cancer Society  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Freedman","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinaa S.","family":"Punglia","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-4111","authenticated-orcid":false,"given":"Ahmedin","family":"Jemal","sequence":"additional","affiliation":[{"name":"Surveillance &amp; Health Equity Science, American Cancer Society  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-5997","authenticated-orcid":false,"given":"Hyuna","family":"Sung","sequence":"additional","affiliation":[{"name":"Surveillance &amp; Health Equity Science, American Cancer Society  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-1023"},{"key":"e_1_2_11_3_1","first-page":"1704","article-title":"Effect of radiotherapy after breast\u2010conserving surgery on 10\u2010year recurrence and 15\u2010year breast cancer death: meta\u2010analysis of individual patient data for 10\u2008801 women in 17 randomised trials","volume":"378","author":"Early Breast Cancer Trialists' Collaborative Group (EBCTCG)","year":"2011","journal-title":"Lancet"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930515)71:10<3054::AID-CNCR2820711027>3.0.CO;2-N"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.72.0722"},{"key":"e_1_2_11_6_1","volume-title":"The 2007 Multiple Primary and Histology Coding Rules","author":"Johnson C","year":"2007"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29179"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","unstructured":"MamounasE BandosH WhiteJ et al.Loco\u2010regional irradiation in patients with biopsy\u2010proven axillary node involvement at presentation who become pathologically node\u2010negative after neoadjuvant chemotherapy: primary outcomes of NRG oncology\/NSABP B\u201051\/RTOG 1304. 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