{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:34:47Z","timestamp":1770068087727,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2023JJA141341"],"award-info":[{"award-number":["2023JJA141341"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2021GXNSFBA220064"],"award-info":[{"award-number":["2021GXNSFBA220064"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC82202544"],"award-info":[{"award-number":["NSFC82202544"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M730801"],"award-info":[{"award-number":["2023M730801"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infection is the most common non\u2010cancer cause of death in patients with lung cancer (LC). However, original research reports with large sample sizes on the epidemiology, pathogen spectrum, immune status changes, and prognosis of these patients are lacking. A retrospective study of LC patients with infection was performed at Guangxi Medical University Cancer Hospital from 2014 to 2023. In total, 699 LC patients with disease complicated by infection were included in the study. The incidence of infection increased from 4.61% in 2014 to 9.77% in 2023 among patients with LC. A total of 109 types of pathogens were detected. The most prevalent pathogenic organisms in each category were bacteria (<jats:italic>Klebsiella pneumoniae<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic>), fungi (<jats:italic>Candida<\/jats:italic> spp. and <jats:italic>Aspergillus<\/jats:italic> spp.), viruses (COVID\u201019 and Epstein\u2013Barr virus), and special pathogens (<jats:italic>Mycobacterium tuberculosis<\/jats:italic> and <jats:italic>Mycoplasma pneumoniae<\/jats:italic>). Upon diagnosis of infection, the total T lymphocyte, helper T cell, Th\/Ts ratio, and B lymphocyte counts decreased, while the natural killer cell and suppressor T\u2010cell counts increased. Infection is a crucial risk factor affecting the prognosis and mortality of patients with LC. The susceptibility of patients with LC to infection may be related to immunodeficiency resulting from antitumor treatment and disease progression.<\/jats:p>","DOI":"10.1002\/ijc.35272","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T15:13:51Z","timestamp":1734362031000},"page":"1470-1479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pathogen spectrum and clinical characteristics of lung cancer patients: A 10\u2010year retrospective study"],"prefix":"10.1002","volume":"156","author":[{"given":"Zhen\u2010Ming","family":"Yang","sequence":"first","affiliation":[{"name":"Medical Oncology of Respiratory Medicine Guangxi Medical University Cancer Hospital  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu\u2010Yu","family":"Qin","sequence":"additional","affiliation":[{"name":"Gastroenterology and Respiratory Internal Medicine Department Guangxi Medical University Cancer Hospital  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Gastroenterology and Respiratory Internal Medicine Department Guangxi Medical University Cancer Hospital  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lun\u2010kai","family":"Yao","sequence":"additional","affiliation":[{"name":"Gastroenterology and Respiratory Internal Medicine Department Guangxi Medical University Cancer Hospital  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai\u2010Qun","family":"Liu","sequence":"additional","affiliation":[{"name":"Gastroenterology and Respiratory Internal Medicine Department Guangxi Medical University Cancer Hospital  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi\u2010Tao","family":"Yu","sequence":"additional","affiliation":[{"name":"Medical Oncology of Respiratory Medicine Guangxi Medical University Cancer Hospital  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Medical Oncology of Respiratory Medicine Guangxi Medical University Cancer Hospital  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liang","sequence":"additional","affiliation":[{"name":"Gastroenterology and Respiratory Internal Medicine Department Guangxi Medical University Cancer Hospital  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Hezhou People's Hospital  Hezhou Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-0521","authenticated-orcid":false,"given":"Shao\u2010Zhang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Medical Oncology of Respiratory Medicine Guangxi Medical University Cancer Hospital  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1935-9393","authenticated-orcid":false,"given":"Ye","family":"Qiu","sequence":"additional","affiliation":[{"name":"Gastroenterology and Respiratory Internal Medicine Department Guangxi Medical University Cancer Hospital  Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.01.006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2020.104161"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw604"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3971\/j.issn.1000\u20108578.2018.17.0993"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3971\/j.issn.1000\u20108578.2015.03.009"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112150\u201020230720\u201000019"},{"key":"e_1_2_11_9_1","volume-title":"Diagnosis for Pulmonary Tuberculosis","author":"Lixia W","year":"2017"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_11_11_1","article-title":"Diagnosis and treatment plan for COVID\u201019 (trialversion 10)","volume":"16","author":"China NHC of the PR of","year":"2023","journal-title":"Chin J Clin Infect Dis"},{"key":"e_1_2_11_12_1","article-title":"Expert consensus on laboratory diagnosis and clinical application of EBV infection","volume":"32","author":"Zhengde X","year":"2018","journal-title":"Chin J Exp Clin Virol"},{"key":"e_1_2_11_13_1","article-title":"Clinical characteristics and T\u2043lymphocyte subsets in 48 acquired immune deficiency syndrome patients with cytomegalovirus infections","volume":"58","author":"Chunhui J","year":"2019","journal-title":"Chin J Nat Med"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890\u2010023\u201002681\u20104"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1051673"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-023-02070-3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103365"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.12.655"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06945-1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01806"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3779\/j.issn.1009\u20103419.2023.102.20"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s182173"},{"key":"e_1_2_11_23_1","article-title":"Association of lymphocyte subsets in peripheral blood with radiotherapy in advanced lung cancer","volume":"5","author":"Xiangchan H","year":"2022","journal-title":"China J Metastatic Cancer"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.09.006"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.11.038"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3720"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0254\u20106450.2018.10.014"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201095686\u20100"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S264276"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1667\/rade\u201022\u201000197.1"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2023.10.001"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.35272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T04:34:17Z","timestamp":1739162057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.35272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/ijc.35272"],"URL":"https:\/\/doi.org\/10.1002\/ijc.35272","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"assertion":[{"value":"2024-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}