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In this study, we aimed to investigate the association between delivery methods, obstetric history, and birth anthropometrics with the risk of CBTs. This study used data from the Childhood Brain Tumour Epidemiology Study of Ontario (CBREO) which included children 0\u201315\u2009years of age and newly diagnosed with CBTs from 1997 to 2003. Multivariable logistic regressions were performed to explore the association between delivery methods, obstetric history, and birth anthropometric variables, with subsequent CBT development. Models were adjusted for maternal and index child characteristics, and stratified by histology where sample size permitted. The use of assistive instruments (forceps or suction) during childbirth was significantly associated with overall CBTs (OR 1.84, 95% CI 1.30\u20132.61) and non\u2010glial tumors (OR 2.57, 95% CI 1.60\u20134.13). Compared to first\u2010born children, those second\u2010born or greater had a lower risk of overall CBT development (OR 0.74, 95% CI 0.55\u20130.98), and glial histological subtype. All other birth characteristic variables explored were not associated with CBTs. The use of assistive devices such as forceps or suction during vaginal delivery carries potential risks, including increased risk of CBT development. There is an inverse association between birth order and CBTs, and future studies examining early childhood common infection may be warranted.<\/jats:p>","DOI":"10.1002\/ijc.35287","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T12:29:12Z","timestamp":1734092952000},"page":"1909-1915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Birth characteristics and the risk of childhood brain tumors: A case\u2013control study in Ontario, Canada"],"prefix":"10.1002","volume":"156","author":[{"given":"Sierra","family":"Cheng","sequence":"first","affiliation":[{"name":"Prosserman Centre for Population Health Research, Lunenfeld\u2010Tanenbaum Research Institute, Sinai Health System  Toronto Ontario Canada"},{"name":"Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-7732","authenticated-orcid":false,"given":"M. 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Elizabeth","family":"Cairney","sequence":"additional","affiliation":[{"name":"Department of Oncology, Children's Hospital, London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrianna","family":"Ranger","sequence":"additional","affiliation":[{"name":"Department of Oncology, Children's Hospital, London Health Sciences Centre  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology, McMaster Children's Hospital, Hamilton Health Sciences  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna L.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital of Eastern Ontario  Ottawa Ontario 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