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T\u2010ALL is associated with the overexpression of major transcription factors (TLX1\/3, TAL1, HOXA) that drive specific transcriptional programmes and constitute the molecular classifying subgroups of T\u2010ALL. Although the dysregulation of transcription factor oncogenes is frequently associated with chromosomal translocations in T\u2010ALL, epigenetic dysregulation resulting in changes to post\u2010translational modifications of histones has also been reported. This includes non\u2010coding intergenic mutations that form oncogenic neo\u2010enhancers. This review will focus on the known epigenetically activating intergenic mutations reported in T\u2010ALL, and will discuss the wider implications of neo\u2010enhancer mutations in cancer.<\/jats:p>","DOI":"10.1002\/ijc.35315","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T06:24:29Z","timestamp":1735885469000},"page":"305-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neo\u2010enhancers in T\u2010cell acute lymphoblastic Leukaemia (T\u2010\n                    <scp>ALL<\/scp>\n                    ) and beyond"],"prefix":"10.1002","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-9287","authenticated-orcid":false,"given":"Charlotte","family":"Smith","sequence":"first","affiliation":[{"name":"Laboratory of Onco\u2010Hematology, Necker Children's Hospital Assistance Publique\u2010H\u00f4pitaux de Paris (AP\u2010HP)  Paris 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