{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:06:49Z","timestamp":1791230809183,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High\u2010risk human papillomavirus (hrHPV) genotype is needed for adequate cervical cancer screening and HPV vaccination program evaluation as recommended by different guidelines. We aimed to assess the rate of HPV infection and HPV genotype distribution using vaginal self\u2010sampling in a cohort of unscreened reproductive\u2010age women in Ethiopia. A community\u2010based cohort study was conducted with women aged 23\u201346 living in Adama, Ethiopia. A total of 885 self\u2010collected vaginal swabs were obtained and tested for hrHPV genotypes with the real\u2010time polymerase chain reaction technique. The overall hrHPV prevalence was 21.1% (187\/885, 95% confidence interval [CI]: 18.5\u201324.0). Among women living with human immunodeficiency virus, 46% (30\/56) (95% CI: 33.7\u201359) were hrHPV positive compared with 19% (157\/820) (95% CI: 16.2\u201322) of human immunodeficiency virus\u2010negative women. The most frequent genotypes were HPV16 (3.1%), HPV51 (3.1%), HPV35 (2.6%), HPV56 (2.6%), HPV52 (2.4%), HPV31 (2.5%), and HPV39 (2.5%). Among the 187 HPV\u2010positive women in self\u2010samples, HPV 16\/18 was found in 21% (39), HPV 16\/18\/45 was found in 24% (44), and HPV 16\/18\/31\/33\/45\/52\/58 was prevalent in 56% (104). Out of 116 biopsies, 7% (8) had cervical intraepithelial lesions and worse identified. Of these eight cervical intraepithelial lesions and worse patients, only 25% tested positive for HPV\u201016; none tested positive for HPV\u201018 or 45. One out of five women tested positive for hrHPV genotypes. Other HPV genotypes not covered by the quadrivalent HPV vaccine but associated with clinically significant cervical high\u2010grade lesions or cancer were detected in 75%. It is more effective to prevent cervical cancer by switching to the nine\u2010valent HPV vaccine.<\/jats:p>","DOI":"10.1002\/ijc.35335","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T08:24:59Z","timestamp":1739521499000},"page":"1995-2009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High\u2010risk human papillomavirus genotypes in previously unscreened reproductive\u2010age women in Ethiopia: A community\u2010based cohort study"],"prefix":"10.1002","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-1992","authenticated-orcid":false,"given":"Habtamu Biazin","family":"Kebede","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"},{"name":"Department of Oncology, Sk\u00e5ne University Hospital Lund University  Lund Sweden"},{"name":"Bacteriology Laboratory Unit Armauer Hansen Research Institute  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selamawit","family":"Mekuria","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sk\u00e5ne University Hospital Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahom","family":"Asegid","sequence":"additional","affiliation":[{"name":"Bacteriology Laboratory Unit Armauer Hansen Research Institute  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6293-7286","authenticated-orcid":false,"given":"Ola","family":"Forslund","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Borgfeldt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology in Link\u00f6ping, Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sk\u00e5ne University Hospital Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adane","family":"Mihret","sequence":"additional","affiliation":[{"name":"Bacteriology Laboratory Unit Armauer Hansen Research Institute  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6100-9303","authenticated-orcid":false,"given":"Tamrat","family":"Abebe","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1381.1999.99723.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2016.07.002"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.1.1-17.2003"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30482-6"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00241-8"},{"key":"e_1_2_12_9_1","unstructured":"BruniL AlberoG SerranoB et al.ICO\/IARC Information Centre on HPV and Cancer (HPV Information Centre).Bruni L Albero G Serrano B Mena M Collado JJ G\u00f3mez D Mu\u00f1oz J Bosch FX de SSIIC on H and C (HPV IC. 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