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This study aims to investigate the prevalence of hearing impairment in this population through comprehensive audiometric testing and analyse the associated factors. A cohort of 187 newly diagnosed NPC patients were recruited from three hospitals. Pre\u2010treatment comprehensive audiometric assessments, including pure\u2010tone audiometry, tympanometry, Eustachian tube function tests and distortion product otoacoustic emissions (DPOAE), were performed to evaluate hearing impairment. Patient characteristics and tumour invasion extent were also recorded. Binary logistic regression was employed to analyse factors associated with hearing impairment. Among the patients, 27.5% of ears showed conductive hearing loss (CHL), 13.6% had sensorineural hearing loss (SNHL), and 10.4% demonstrated mixed hearing loss. Additionally, 43.6% of ears exhibited abnormal tympanograms, 86.1% had Eustachian tube dysfunction, and 77.3% failed the DPOAE test. Multivariable analysis identified subjective hearing symptoms, mastoiditis, and invasion of the tensor veli palatini muscle and Eustachian tube as factors associated with CHL. T stage, mastoiditis, and invasion of the tensor veli palatini muscle and nasal cavity were linked to abnormal tympanograms. T stage, sinusitis, and invasion of the levator veli palatini muscle significantly affected Eustachian tube function, while age influenced both SNHL and DPOAE results. Hearing impairment is prevalent among newly diagnosed NPC patients, with over half exhibiting various forms. Comprehensive baseline audiometric assessment in this population is crucial for developing individualized treatment strategies and enabling early intervention to prevent further hearing deterioration.<\/jats:p>","DOI":"10.1002\/ijc.35358","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T13:50:04Z","timestamp":1738677004000},"page":"239-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Baseline audiometric assessment of newly diagnosed nasopharyngeal carcinoma patients: a multicentre cross\u2010sectional study"],"prefix":"10.1002","volume":"157","author":[{"given":"Housheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The First Affiliated Hospital of Guangxi Medical University  Nanning China"},{"name":"State Key Laboratory of Targeting Oncology Guangxi Medical University  Guangxi China"},{"name":"Key Laboratory of Early 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