{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:25:43Z","timestamp":1787761543937,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000769","name":"University of Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>SARS\u2010CoV\u20102 continues to spread across the world as a highly transmissible endemic disease. For many cancer patients, SARS\u2010CoV\u20102 infection is unavoidable. It continues to disrupt cancer care, causing treatment delays and major psycho\u2010socio\u2010medical issues. At present, there is limited evidence on safe prescribing of anti\u2010cancer therapy, and safe treatment restart following SARS\u2010CoV\u20102 infection. We conducted a prospective cohort study involving 406 COVID\u201019\u2010positive cancer patients across five UK cancer centres and collected data on delay durations, COVID\u201019 symptoms and mortality, to ascertain the effect of treatment interruptions. Patients were studied between May 2022 and March 2023, during which Omicron variants of SARS\u2010CoV\u20102 were predominant. Mean treatment interruption was 12.7\u2009days (standard deviation 47.3\u2009days). Upon resuming anti\u2010cancer therapy, 8.5% experienced COVID\u201019 symptom progression, and 1.2% succumbed to COVID\u201019\u2010related mortality. Patients with haematological cancers had a 3.4\u2010fold increased risk of severe symptoms at 4\u2009weeks compared to solid tumour patients. Higher symptom burden at COVID\u201019 diagnosis was associated with a 3.0\u2010fold increase in symptom severity at 4\u2009weeks following treatment restart. At 8\u2009weeks following restart, 2.1% had increased morbidity or mortality. We highlight the ongoing impact of COVID\u201019 on patients and cancer care, and the risk of resuming cancer treatments in patients with symptomatic COVID\u201019. Although the risk of mortality is relatively low upon treatment resumption, personalised approaches assessing cancer diagnosis and SARS\u2010CoV\u20102 status are crucial. Treatments are also stopped due to other infectious conditions and our results could be reviewed in the context of yearly influenza pandemics.<\/jats:p>","DOI":"10.1002\/ijc.35377","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:40:14Z","timestamp":1741758014000},"page":"2087-2093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safe prescribing in cancer patients during the\n                    <scp>COVID<\/scp>\n                    \u201019 pandemic and outcomes following restart of cancer care following\n                    <scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102 infection: The\n                    <scp>COV<\/scp>\n                    \u2010\n                    <scp>SPOT<\/scp>\n                    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