{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:51:23Z","timestamp":1791402683397,"version":"4.3.3"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1313105"],"award-info":[{"award-number":["2018YFC1313105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3600805"],"award-info":[{"award-number":["2022YFC3600805"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073024"],"award-info":[{"award-number":["82073024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172555"],"award-info":[{"award-number":["82172555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81861138041"],"award-info":[{"award-number":["81861138041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7242023"],"award-info":[{"award-number":["7242023"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Gastric microbiota and metabolites may interact and play collaborative roles in the carcinogenesis process. This study aims to investigate differential metabolites and microbes, as well as the possible roles of microbe\u2010metabolite interactions in gastric cancer (GC) development. Targeted metabolomics assays and 16S rRNA sequencing were performed to compare metabolic and microbial profiles in gastric tissues from subjects with superficial gastritis\/chronic atrophic gastritis (SG\/CAG), intestinal metaplasia\/low\u2010grade intraepithelial neoplasia (IM\/LGIN) and GC. Significant differences were found in metabolic and microbial profiles between the GC and SG\/CAG or IM\/LGIN groups, respectively (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). By comparing GC with the other lesions, 69 differential metabolites mainly comprised triglycerides and phosphatidylcholines, and 21 differential microbes included\n                    <jats:italic>Peptostreptococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Dialister<\/jats:italic>\n                    ,\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    , and\n                    <jats:italic>Streptococcus anginosus<\/jats:italic>\n                    (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05). The altered metabolites and microbes in GC were both significantly enriched in the glycerophospholipid metabolism pathway, in which the predicted down\u2010regulation of phospholipase C (plc) and up\u2010regulation of 1\u2010acyl\u2010sn\u2010glycerol\u20103\u2010phosphate acyltransferase (plsC) by microbiota may affect phosphatidylcholine hydrolysis and triglyceride biosynthesis modules. More and stronger microbe\u2010metabolite correlations in GC compared to the other lesion group further supported the potential microbial regulations to the important metabolites in gastric carcinogenesis, such as\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    and phosphatidylcholines (.32\u2009\u2264\u2009\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2264\u2009.57, all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05),\n                    <jats:italic>Peptostreptococcus<\/jats:italic>\n                    (.36\u2009\u2264\u2009\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2264\u2009.60, all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05) or\n                    <jats:italic>Dialister<\/jats:italic>\n                    (.36\u2009\u2264\u2009\n                    <jats:italic>r<\/jats:italic>\n                    \u2009\u2264\u2009.62, all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05) and triglycerides. We simultaneously identified differential metabolites and microbes and their altered correlations between GC and gastric lesions. The main GC\u2010associated phosphatidylcholines and triglycerides may be affected by gastric microbes, which provides new perspectives on the microbiota\u2010metabolite interactions during the development of GC.\n                  <\/jats:p>","DOI":"10.1002\/ijc.35392","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:39:26Z","timestamp":1741736366000},"page":"2389-2400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Integrative metabolomics and microbiomics analysis reveals distinctive microbiota\u2010metabolites interactions in gastric carcinogenesis"],"prefix":"10.1002","volume":"156","author":[{"given":"Xiao\u2010Wen","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong\u2010Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education\/Beijing), Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8336-5552","authenticated-orcid":false,"given":"Wen\u2010Qing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Cancer Epidemiology Peking University Cancer Hospital &amp; Institute  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Dong","family":"Liu","sequence":"additional","affiliation":[{"name":"Health Bureau of Linqu County  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan\u2010Fu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Health Bureau of Linqu County  Weifang 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