{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:50:19Z","timestamp":1791010219356,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The heterogeneity in prognostic survival and treatment response of hepatocellular carcinoma (HCC) limits the accurate assessment of HCC\u2010specific mortality. This study aimed to identify potential HCC subtypes through latent class analysis (LCA) to improve HCC\u2010specific mortality prediction and optimize treatment recommendations. We analyzed data from 7746 HCC patients in the Surveillance, Epidemiology, and End Results (SEER) databases, incorporating demographic and clinicopathological information and applying LCA to identify HCC subtypes. Prognostic survival and treatment response across different HCC subtypes were evaluated utilizing Cox proportional hazards regression and competing risks models. The classification was externally validated with data from 6791 patients. Four HCC subtypes (LCAC1\u2013LCAC4) were determined. Compared with LCAC1, both LCAC2 (HR = 1.887, <jats:italic>p<\/jats:italic> &lt; .001) and LCAC4 (HR = 1.317, <jats:italic>p<\/jats:italic> &lt; .001)\u00a0were associated with significantly shorter overall survival. LCAC2 had the highest HCC\u2010specific mortality (HR: 2.395, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), followed by LCAC4 (HR: 1.531, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and LCAC3 (HR: 1.424, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). LCAC3 was associated with the lowest risk of non\u2010HCC\u2010specific mortality (HR: 0.613, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Surgical treatment, particularly preoperative systemic therapy, significantly improved survival across all HCC subtypes, whereas chemotherapy and radiotherapy had limited efficacy in LCAC1 and LCAC3 patients. External validation corroborated these findings. This study provides a classification system that differentiates HCC\u2010specific mortality, facilitating accurate survival stratification and treatment recommendations, and provides valuable insight for clinical decision\u2010making.<\/jats:p>","DOI":"10.1002\/ijc.35399","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T11:24:26Z","timestamp":1741778666000},"page":"325-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Latent class analysis\u2010derived classification for cancer\u2010specific death stratification of hepatocellular carcinoma"],"prefix":"10.1002","volume":"157","author":[{"given":"Xiaoyan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Gestational and Toxic Hepatopathy Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Medicine Fujian Medical University Union Hospital  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Oncology Medicine Fujian Medical University Union Hospital  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Fuzong Clinical Medical College of Fujian Medical University  Fuzhou Fujian People's Republic of China"},{"name":"Department of Radiotherapy The 900th Hospital of Joint Logistic Support Force, PLA  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8476-6228","authenticated-orcid":false,"given":"Qiong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Oncology Medicine Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou Fujian People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.11.024"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.7989"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-024-00764-w"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-018-0915-0"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i15.4141"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.166"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.025"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-024-01296-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyae063"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-03972-8"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5706"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000561"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-225093"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15256"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202006\u20102522OC"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.03.219"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-023-00412-w"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2024.07.2136"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000933"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2021.01.004"},{"key":"e_1_2_12_23_1","unstructured":"The SEER program.SEER Incidence Data \u2010 SEER Data & Software [Internet].SEER[cited 2024 Sep 29]. 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