{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:59:19Z","timestamp":1793411959836,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To prevent thrombosis in patients with polycythemia vera (PV), achieving a complete hematologic response (CHR) is highly recommended in practice. In addition, a reduced <jats:italic>JAK2<\/jats:italic> V617F mutation burden is expected to have a disease\u2010modifying effect, and its molecular response (MR) is currently of significant interest. This study aimed to assess the association between CHR and MR in patients with PV following treatment with ropeginterferon alfa\u20102b. This phase 2, single\u2010arm, open\u2010label, investigator\u2010initiated trial was conducted at 16 sites in South Korea. Ninety\u2010nine patients were treated with ropeginterferon alfa\u20102b subcutaneously every 2\u2009weeks, at doses of 250\u2009\u03bcg (week 1), 350\u2009\u03bcg (week 3), and 500\u2009\u03bcg (week 5), until week 48. CHRs were 27% (25\/94), 46% (40\/87), 56% (47\/84), and 63% (51\/81) at 12, 24, 36, and 48\u2009weeks, respectively. The MR rates were 32% (28\/88), 36% (29\/81), 49% (38\/77), and 57% (42\/74) at 12, 24, 36, and 48\u2009weeks, respectively. The Phi Coefficient for the association between CHR and MR was 0.6146 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) at 48\u2009weeks. In the subgroup analysis, patients with hydroxyurea resistance or intolerance, and those who were hydroxyurea\u2010na\u00efve, had similar results in terms of the CHR. In conclusion, CHR and MR were observed to be associated in patients with PV treated with ropeginterferon.<\/jats:p>","DOI":"10.1002\/ijc.35411","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T04:14:18Z","timestamp":1742012058000},"page":"526-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Hematologic and molecular responses to ropeginterferon alfa\u20102b therapy of polycythemia vera: 48\u2010week results from a prospective study"],"prefix":"10.1002","volume":"157","author":[{"given":"Seug Yun","family":"Yoon","sequence":"first","affiliation":[{"name":"Division of Hematology &amp; Medical Oncology, Department of Internal Medicine Soonchunhyang University Seoul Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Soo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National 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