{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:56:02Z","timestamp":1787601362439,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adjuvant anthracyclines and taxanes reduce recurrence and death in early\u2010stage breast cancer (EBC) patients, but toxicity is a concern. Studies show conflicting results on the correlation between body mass index (BMI) and outcomes. Limited data exist on the efficacy of adjuvant taxanes among BMI categories and the impact of different taxane\u2010based chemotherapies (paclitaxel vs. docetaxel) on disease recurrence. Here, we present a pooled analysis of 13,486 EBC patients treated with adjuvant anthracyclines\u2009\u00b1\u2009taxanes from seven GEICAM and TRIO trials (1996\u20132008) conducted. Patients were classified into four BMI categories: normal (&lt;25.0), overweight (25.0\u201329.9), obese (30.0\u201334.9), and severely obese (\u226535.0). BMI was evaluated as a predictive factor for the efficacy and toxicity of taxane\u2010based chemotherapy. Our results show the following findings: patients' distribution by BMI was 44% normal, 33% overweight, 16% obese, and 8% severely obese. Seventy\u2010nine percent received taxane\u2010based chemotherapy. Ten\u2010year invasive disease\u2010free survival (iDFS) was 71%, 70%, 68%, and 64% for normal, overweight, obese, and severely obese patients, respectively. Obese and severely obese patients had significantly worse outcomes (HR 1.15 and 1.29, respectively). Invasive disease\u2010free survival with docetaxel vs. non\u2010docetaxel was significant in the normal BMI group, while iDFS with paclitaxel was significant in the obese group. Relevant toxicity was observed in 5%, 5.5%, 5.9%, and 9.3% of normal, overweight, obese, and severely obese patients who received docetaxel. In conclusion, heavier EBC patients had a worse prognosis with adjuvant taxane\u2010based chemotherapy. Normal BMI patients benefited more from docetaxel, while obese patients benefited more from paclitaxel.<\/jats:p>","DOI":"10.1002\/ijc.35432","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T11:53:07Z","timestamp":1744285987000},"page":"709-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Body mass index as a predictive factor for efficacy of adjuvant taxane\u2010based chemotherapy in early\u2010stage breast cancer patients: A pooled analysis from adjuvant <scp>GEICAM<\/scp> Spanish Breast Cancer Group and <scp>TRIO<\/scp> Translational Research in Oncology Group studies"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6880-0301","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Garc\u00eda\u2010Saenz","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos Instituto de Investigaci\u00f3n Sanitaria San 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