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There is a need for improvement of screening methods due to interval cancers and radiation exposure. The aim of the TESTBREAST study is to develop a blood test suitable for early diagnosis. Here, the clinical composition of participants is provided. From 2010 to 2022, 1108 women were included in the TESTBREAST study, with currently 750 participants suitable for serum analysis.<\/jats:p><jats:p>The median follow\u2010up was 7\u2009years [1\u201314]. Of the 1108 participants, 70% (<jats:italic>n<\/jats:italic>\u2009=\u2009728) had a PV. BC was diagnosed in 16.5% (<jats:italic>n<\/jats:italic>\u2009=\u2009124), mainly stage I\u2010II (68.5%), and mostly BRCA1 (<jats:italic>n<\/jats:italic>\u2009=\u200947, 47%) and BRCA2 (<jats:italic>n<\/jats:italic>\u2009=\u200929, 29%) carriers. Invasive cancer was diagnosed in 100 cases: 76% (<jats:italic>n<\/jats:italic>\u2009=\u200976) had a PV with a median age of 49 [26\u201368] at diagnosis, whereas 24% (<jats:italic>n<\/jats:italic>\u2009=\u200924) had a FP, with a median age of 51\u2009years [25\u201365]. The general population (the Netherlands) is aged 61\u2009years on average at diagnosis. Triple negative breast cancer (TNBC) occurred in 51% (<jats:italic>n<\/jats:italic>\u2009=\u200939) of the TESTBREAST women with a PV, whereas this was 11% in the general population. Within the TESTBREAST cohort, BRCA carriers were younger at diagnosis and often had the aggressive TNBC subtype. Improvement of current screening methods for early detection is especially important for this group of high\u2010risk women to reduce interval cancers, exposure to radiation, and to improve survival.<\/jats:p>","DOI":"10.1002\/ijc.35444","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T13:56:36Z","timestamp":1744725396000},"page":"741-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The <scp>TESTBREAST<\/scp> journey: Revisiting the importance of early detection by frequent screening of women at high risk of breast cancer"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-9601","authenticated-orcid":false,"given":"Layla","family":"Andour","sequence":"first","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-1975","authenticated-orcid":false,"given":"Sophie C.","family":"Hagenaars","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiki","family":"Vangangelt","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janneke","family":"Aalberts","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Rebattu","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorien M. A. Berends","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elma Meershoek\u2010Klein","family":"Kranenbarg","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja N.","family":"Gaarenstroom","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christi J.","family":"van Asperen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob A. E. M.","family":"Tollenaar","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma E.","family":"Mesker","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the TESTBREAST study team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.4137\/BCBCR.S18715"},{"key":"e_1_2_16_3_1","unstructured":"IKNL.Netherlands Comprehensive Cancer Organisation (NKR).2024https:\/\/iknl.nl\/borstkankercijfers"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.04.003"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv022"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.6204"},{"key":"e_1_2_16_7_1","unstructured":"FMS.Borstkanker: Screening (Breast cancer\u2014Screening): Federatie Medisch Specialisten.https:\/\/richtlijnendatabase.nl\/richtlijn\/borstkanker\/screening\/screeningsmiddelen\/mammografie.html"},{"key":"e_1_2_16_8_1","unstructured":"NCCN.National Comprehensive Cancer Network (NCCN): Clinical Practice Guidelines in Oncology Breast Cancer Screening and Diagnosis.https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/breast-screening.pdf"},{"key":"e_1_2_16_9_1","unstructured":"NICE. 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