{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:51:42Z","timestamp":1791917502735,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R37CA271187"],"award-info":[{"award-number":["R37CA271187"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Personal history of cancer is an independent risk factor for developing lung cancer. However, it is not considered in the current US lung cancer screening (LCS) guidelines. In this study, we assessed the risk of developing lung cancer among cancer survivors across 24 different sites of first primary cancer stratified by their LCS eligibility status. Using data from the Patient History Database at the University of Texas MD Anderson Cancer Center, we calculated and compared the cumulative incidence of second primary lung cancer, the overall and the LCS eligibility status\u2010specific, stratified by the site of first primary cancer among cancer survivors. We found that among lung, head and neck (H&amp;N), bladder, cervical, breast, and prostate cancer survivors, the risks of second primary lung cancer were statistically significantly higher compared to the overall risk among all cancer survivors (i.e., all cancer sites combined). Risk ratios (RR) ranged between 1.14 (95%CI:1.00\u20131.28, <jats:italic>p<\/jats:italic>\u2009=\u20090.0431) among prostate cancer survivors to 2.9 (95%CI:2.58\u20133.26, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) among H&amp;N cancer survivors. Other than first primary lung cancer (RR: 1.33; 95%CI:1.14\u20131.57; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), H&amp;N (RR: 1.73; 95%CI:1.45\u20132.05; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and bladder (RR: 1.32; 95%CI:1\u20131.74; <jats:italic>p<\/jats:italic>\u2009=\u20090.0483) cancer survivors, who were non\u2010eligible for LCS, had significantly higher lung cancer risk than all cancer survivors. In conclusion, H&amp;N, bladder, cervical, breast, and prostate cancer survivors have a high risk of developing second primary lung cancer. Specifically, personal history of H&amp;N and bladder cancer, even among non\u2010eligible for LCS individuals, remain at a sufficiently high risk, which warrants further consideration as an independent eligibility factor for LCS guidelines.<\/jats:p>","DOI":"10.1002\/ijc.35452","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T08:05:51Z","timestamp":1744963551000},"page":"941-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of second primary lung cancer among cancer survivors stratified by the site of first primary cancer and the lung cancer screening eligibility status"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-2056","authenticated-orcid":false,"given":"Sara","family":"Nofal","sequence":"first","affiliation":[{"name":"Department of Health Services Research The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4538-6539","authenticated-orcid":false,"given":"Edwin","family":"J Ostrin","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic\/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Imaging Physics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Scheet","sequence":"additional","affiliation":[{"name":"Department of Epidemiology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara B.","family":"Antonoff","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"V Heymach","sequence":"additional","affiliation":[{"name":"Department of Thoracic\/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3462-2137","authenticated-orcid":false,"given":"Iakovos","family":"Toumazis","sequence":"additional","affiliation":[{"name":"Department of Health Services Research The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2172"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911793"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.1117"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001764"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21731"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djae135"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604158"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1211776"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.0204"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.07.007"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.2776"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7069"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.07.001"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408\u2010012\u20109418\u20104"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.09.01"},{"key":"e_1_2_12_18_1","first-page":"1358","article-title":"Multiple primary malignant tumors. A survey of the literature and statistical study","volume":"16","author":"Warren S","year":"1932","journal-title":"Am J Cancer"},{"issue":"1","key":"e_1_2_12_19_1","first-page":"37","article-title":"Primary care of adult cancer survivors","volume":"110","author":"Carek S","year":"2024","journal-title":"Am Fam Physician"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010018\u20104530\u20103"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13351"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0305670"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231807"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959\u20108049(02)00089\u20108"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010012\u20109957\u20102"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1764"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3857\/roj.2020.00857"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.05.034"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/igc.0000000000000950"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21040"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e3282fafd0a"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.11.001"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S304332"},{"key":"e_1_2_12_34_1","doi-asserted-by":"crossref","unstructured":"JoungJY KwonW\u2010A LimJ et al.Second primary cancer risk among kidney cancer patients in Korea: a population\u2010based cohort study.2018;50(1):293\u2010301. doi:10.4143\/crt.2016.543","DOI":"10.4143\/crt.2016.543"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3861"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010015\u20101426\u20103"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2021.1994639"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010021\u201001767\u20102"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102050.2011.01273.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji278"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2022.08.003"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010019\u20100237\u20101"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538\u20107445.Am2015\u2010lb\u2010184"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(05)70387\u20109"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)70387\u20100"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28326"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz164"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2024.09.233"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102743"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.7326\/M22\u20102216"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33835"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.35452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:31:53Z","timestamp":1752755513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.35452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,18]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/ijc.35452"],"URL":"https:\/\/doi.org\/10.1002\/ijc.35452","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,18]]},"assertion":[{"value":"2024-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}