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In this study, we assessed the efficacy of carboplatin\u2013gemcitabine as a systemic chemotherapy regimen administered to patients with high\u2010grade recurrent meningiomas after observing incidental tumour shrinkage in one patient. Carboplatin\u2013gemcitabine was offered on a compassionate basis to French patients with high\u2010grade recurrent meningioma within the framework of the French <jats:italic>R\u00e9union d'orientation th\u00e9rapeutique des m\u00e9ningiomes de haut grade<\/jats:italic> (OMEGA) multidisciplinary board, which discusses all meningioma cases nationwide that are not amenable to standard treatment (surgery or radiotherapy). We retrospectively analysed the efficacy of this treatment in French patients from 2019 to 2023. We evaluated the three\u2010dimensional volumetric kinetics of the tumour, progression\u2010free survival (PFS), and safety. Carboplatin\u2013gemcitabine slowed tumour growth for several months in some heavily pretreated patients despite the failure of previous systemic therapies. The 6\u2010month PFS rate for the cohort of six patients was 50% (95% confidence interval, [22.5\u2013100%]). Safety was characterised by asthenia and manageable haematological toxicity. Our results provide encouraging data on the efficacy of carboplatin\u2013gemcitabine for meningiomas and should be validated in a prospective trial. Despite the small number of patients, our study included all French patients treated for a 4\u2010year period and should be considered alongside other previously published studies, which also included few patients due to the rarity of the disease. Our findings highlight the importance of national networks for managing these patients and the need for multicentre trials.<\/jats:p>","DOI":"10.1002\/ijc.35453","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T09:26:21Z","timestamp":1745227581000},"page":"837-845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Carboplatin\u2013gemcitabine for refractory high\u2010grade meningiomas: A study from the French national <scp>OMEGA<\/scp> consortium"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7963-3887","authenticated-orcid":false,"given":"Mathieu","family":"Larroquette","sequence":"first","affiliation":[{"name":"Department of Medical Oncology H\u00f4pital Saint Andr\u00e9, CHU de Bordeaux  Bordeaux France"},{"name":"Bordeaux University, CNRS UMR 5095, IBGC  Bordeaux 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