{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:11:13Z","timestamp":1792192273396,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lichen sclerosus (LSc) is a chronic inflammatory disease affecting the anogenital area and having malignant potential. Population\u2010based data on the incidence of LSc in men and associated cancer risk are sparse. In the Danish Pathology Register, we identified all men with histologically verified penile LSc 1997\u20132022 and calculated incidence rates. Through linkage with the Danish Cancer Registry, standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were computed as relative risk estimates of penile squamous cell carcinoma (SCC) and non\u2010penile cancer in men with penile LSc (1978\u20132019) compared with background population rates. During the study period, the age\u2010standardized incidence rate of penile LSc more than doubled, being 17.9 per 100,000\u2009person\u2010years in the most recent time (2021\u20132022). The age\u2010specific incidence increased with age and was highest in ages 70\u201379\u2009years (29.2 per 100,000\u2009person\u2010years). Compared with the general population, men with penile LSc had an increased rate of penile SCC (SIR\u2009=\u200915.5, 95% CI: 12.0\u201319.5), which increased with follow\u2010up length and younger age at LSc diagnosis. Rates of non\u2010penile cancers were mostly close to unity except for lung cancer (SIR\u2009=\u20090.6, 95% CI: 0.5\u20130.7). This nationwide study showed an increased incidence of histologically verified penile LSc over the past 26\u2009years. Importantly, men with penile LSc had nearly 16 times higher rate of penile SCC compared with the general population. There was no strong association with the non\u2010penile cancers, except for a lower rate of lung cancer, suggesting that the malignant potential of LSc is caused by local factors rather than a general cancer predisposition.<\/jats:p>","DOI":"10.1002\/ijc.35454","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T21:39:36Z","timestamp":1745012376000},"page":"1086-1093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Histologically verified penile lichen sclerosus\u2014Incidence in Denmark over 26\u2009years and long\u2010term risk of penile and non\u2010penile cancer"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9304-1594","authenticated-orcid":false,"given":"Marianne Gardar","family":"St\u00e6rk","sequence":"first","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Institute  Copenhagen 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of Virus, Lifestyle and Genes Danish Cancer Institute  Copenhagen Denmark"},{"name":"Department of Pathology Zealand University Hospital Roskilde  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-1398","authenticated-orcid":false,"given":"Susanne K.","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Institute  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Gynecology Copenhagen University Hospital Rigshospitalet  Copenhagen 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