{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:24:48Z","timestamp":1787761488694,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20224Y0080"],"award-info":[{"award-number":["20224Y0080"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20214Y0219"],"award-info":[{"award-number":["20214Y0219"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To investigate the efficacy of the levonorgestrel\u2010releasing intrauterine system (LNG\u2010IUS) on recurrence and fertility outcomes during controlled ovarian stimulation (COS) in patients with early stage endometrioid endometrial carcinoma (EEC) and endometrial atypical hyperplasia (EAH) following successful fertility\u2010preserving treatment. We reviewed the patients with Grade 1 presumed Stage IA EEC or EAH who underwent in vitro fertilization and embryo transfer after successful fertility\u2010sparing treatment. A total of 176 women were enrolled in this study, undergoing 318\u2009cycles of COS and 290\u2009cycles of embryo transfer (ET). Twenty\u2010one percent (37\/176) patients have an LNG\u2010IUS insertion during the initial ovarian stimulation, and the median follow\u2010up time for this cohort was 61.3\u2009months (interquartile range [IQR], 39.0\u201376.6\u2009months), while it was 60.5\u2009months for the other cohort (IQR, 44.9\u201380.3\u2009months). Disease recurrence was experienced by 34.7% (61\/176) of the patients. Compared to the non\u2010LNG\u2010IUS group, the LNG\u2010IUS group had a lower recurrence rate 1\u2009year after COS (5.4% (2\/37) versus 20.9% (29\/139),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.034). The use of LNG\u2010IUS was associated with a reduced recurrence rate 1\u2009year after COS (hazard ratio\u2009=\u20090.203, 95% confidence interval [0.042\u20130.984],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.048). The overall clinical pregnancy rate reached as high as 65.3% (115\/176), while the cumulative live birth rates were up to 46.6% (85\/176). We found that LNG\u2010IUS during COS did not impact oocyte yield, ET, or pregnancy outcomes. The placement of LNG\u2010IUS during COS in EEC\/EAH patients is worth considering, as it is likely to reduce the recurrence of endometrial lesions without affecting fertility outcomes.\n                  <\/jats:p>","DOI":"10.1002\/ijc.35465","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T10:20:07Z","timestamp":1747218007000},"page":"1168-1182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of levonorgestrel\u2010releasing intrauterine system on recurrence and fertility outcomes during assisted reproduction after complete remission of early endometrioid endometrial cancer and precancerous lesions: A retrospective cohort study"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3814-2970","authenticated-orcid":false,"given":"Qujia","family":"Gama","sequence":"first","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"},{"name":"Department of Cervix Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"},{"name":"Department of Ultrasound Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"},{"name":"Department of Pathology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhen","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"},{"name":"Reproductive Medicine Center Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Laboratory of Female Reproductive Endocrine\u2010Related Diseases Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29049"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-002230"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0006"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.01.014"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.11.043"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2018.29.e21"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.01.003"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0136-7"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.08.011"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31827a0643"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.09.078"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605086"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.01.001"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.12.010"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2018.07.001"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.03.022"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2013.09.009"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.01.004"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2024.07.018"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16108"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2021.32.e57"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.11.018"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.09.035"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv066"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00690"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01133388"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der037"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.08.077"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.09.026"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2022.11.009"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2023.103750"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-023-07170-x"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.07.700"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00808-y"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.05.043"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.05.012"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.07.986"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490100073030"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu011"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60428-2"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.01.058"},{"issue":"1","key":"e_1_2_13_44_1","article-title":"Granulocyte\u2010colony stimulating factor administration for subfertile women undergoing assisted reproduction","volume":"1","author":"Kamath MS","year":"2020","journal-title":"Cochrane Database Syst Rev"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.35465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.35465","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.35465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:54:27Z","timestamp":1787759667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.35465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,9,15]]}},"alternative-id":["10.1002\/ijc.35465"],"URL":"https:\/\/doi.org\/10.1002\/ijc.35465","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"2024-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}