{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:49:01Z","timestamp":1792676941311,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sarcopenia is characterised by low grip strength, muscle quantity or quality, and physical performance. This study investigated the associations of sarcopenia and its components with cancer incidence. A prospective cohort study was conducted utilising data from the UK Biobank. Sarcopenia and its components were defined according to the European Working Group on Sarcopenia in Older People criteria (EWGSOP2 2019). Cox proportional hazard models adjusted for sociodemographic, lifestyle, and health\u2010related factors were performed. Overall, 63,379 out of 414,094 study participants had an incident diagnosis of cancer during a median follow\u2010up of 11.7\u2009years. In total, 32,286 participants had probable sarcopenia and 934 confirmed\/severe sarcopenia at recruitment. Combined probable, confirmed, and severe sarcopenia was associated with a higher risk of liver (hazard ratio [HR]\u2009=\u20091.65, 95% confidence interval [CI]: 1.17\u20132.33), haematological (HR\u2009=\u20091.22, 95% CI: 1.01\u20131.46), and colorectal cancer (HR\u2009=\u20091.21, 95% CI: 1.04\u20131.41) in males, but not in females. The components of sarcopenia were associated with a higher risk of several cancers, including low grip strength (with liver, haematological and colorectal cancer in males), low muscle mass index (oesophageal in females and oral cancer in males), and slow walking pace (liver and lung in males, lung and overall cancer in females). Compared to participants with non\u2010sarcopenic obesity, those with sarcopenic obesity had a higher risk of colorectal cancer in males (HR\u2009=\u20091.31, 95% CI: 1.03\u20131.68). Our study suggests that sarcopenia, sarcopenia components, and sarcopenic obesity can be associated with risk for several cancers, mainly of the gastrointestinal tract and in males. Thus, early identification of sarcopenia components may benefit cancer prevention.<\/jats:p>","DOI":"10.1002\/ijc.35480","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T08:45:05Z","timestamp":1747817105000},"page":"1316-1332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations of sarcopenia, sarcopenia components and sarcopenic obesity with cancer incidence: A prospective cohort study of 414,094 participants in <scp>UK<\/scp> Biobank"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-5753","authenticated-orcid":false,"given":"Panagiotis","family":"Filis","sequence":"first","affiliation":[{"name":"Department of Hygiene and Epidemiology University of Ioannina School of Medicine  Ioannina Greece"},{"name":"Department of Medical Oncology University of Ioannina School of Medicine  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos K.","family":"Papagiannopoulos","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology University of Ioannina School of Medicine  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Markozannes","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology University of Ioannina School of Medicine  Ioannina Greece"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos V.","family":"Chalitsios","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology University of Ioannina School of Medicine  Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-2462","authenticated-orcid":false,"given":"Ioannis","family":"Zerdes","sequence":"additional","affiliation":[{"name":"Department\u2009of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"},{"name":"Theme Cancer Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6059-0194","authenticated-orcid":false,"given":"Antonios","family":"Valachis","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Papandreou","sequence":"additional","affiliation":[{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), Neuro\u00c8pia Group Hospital Universitari Sant Joan de Reus  Reus (Tarragona) Spain"},{"name":"Department of Nutrition and Dietetics Sciences, School of Health Sciences Hellenic Mediterranean University (HMU)  Siteia Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-4436","authenticated-orcid":false,"given":"Sofia","family":"Christakoudi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-8472","authenticated-orcid":false,"given":"Konstantinos K.","family":"Tsilidis","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology University of Ioannina School of Medicine  Ioannina Greece"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12147"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328358d59b"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/50.5.1231"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31138-9"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab148"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12783"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57379-3_19"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155533"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00102"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14091910"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01249"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.11.006"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10235552"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e3181aa36b8"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12503"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.11.004"},{"issue":"1","key":"e_1_2_11_21_1","first-page":"21","article-title":"Power comparisons of Shapiro\u2010Wilk, Kolmogorov\u2010Smirnov, Lilliefors and Anderson\u2010Darling tests","volume":"2","author":"Razali NM","year":"2011","journal-title":"Analytics"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1977.10480613"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1995.tb02031.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-006-0073-1"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3182746"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2020.tb00136.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-985"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3361-2"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.4161\/21623945.2014.964075"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.4161\/adip.22500"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2018.03.004"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.582258"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/ITT.S29834"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12863"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00587-2"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33697"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1473"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0246-z"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(08)70153\u20100"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071816-064827"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005378"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.1.81"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000004329"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00195"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-018-1139-9"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.35480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T06:43:36Z","timestamp":1754721816000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.35480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/ijc.35480"],"URL":"https:\/\/doi.org\/10.1002\/ijc.35480","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]},"assertion":[{"value":"2024-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}