{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:33:43Z","timestamp":1788993223221,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In recent years, there has been increasing interest in the possible prognostic impact of concomitant medications in patients with cancer treated with immunotherapy combinations. This real\u2010world analysis aims to evaluate the impact of concomitant medications on survival outcomes in patients with advanced biliary tract cancer (BTCs) treated with cisplatin, gemcitabine and durvalumab (CGD) therapy. The study cohort included patients with a diagnosis of advanced BTCs who were taking concomitant medications for their comorbidities before the start of CGD. The primary objectives were overall survival (OS) and progression\u2010free survival (PFS). The initial population consisted of 666 patients, who were retrospectively collected from 41 sites in 12 countries. Data on concomitant medications were available for 493 patients. After a median follow\u2010up of 8.8\u2009months (95% CI: 7.8\u20139.8), patients who did not take steroids (prednisone &gt;10\u2009mg\/day or equivalent) or nonsteroidal anti\u2010inflammatory drugs (NSAIDs) and opioids, before the start of CGD, had longer OS and PFS in univariate analysis. The multivariate analysis confirmed longer OS for patients who did not take steroids. Patients who did not take steroids had an OS of 14.8\u2009months (95% CI: 13.1\u201329.1) versus 5.0\u2009months (95% CI: 2.14\u201311.32) of patients who took prednisone &gt;10\u2009mg\/day or equivalent. No differences were reported in terms of overall response rate (ORR), disease control rate (DCR) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20091.0 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.16, respectively), and safety profile between the two groups. Our analysis suggests that patients who did not receive steroids before the start of GCD had longer survival and highlighted the relevance of balancing concomitant medications and chemoimmunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70009","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T08:49:23Z","timestamp":1752223763000},"page":"2092-2102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Negative impact of corticosteroid use on outcome in patients with advanced\n                    <scp>BTCs<\/scp>\n                    treated with cisplatin, gemcitabine, and durvalumab: A large real\u2010life worldwide population"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0408-5721","authenticated-orcid":false,"given":"Federica Lo","family":"Prinzi","sequence":"first","affiliation":[{"name":"Operative Research Unit of Medical 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