{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:22:25Z","timestamp":1790871745833,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Previous studies in solid tumors link high physical activity (PA) levels to lower cancer recurrence risk, but evidence is lacking for patients with non\u2010muscle invasive bladder cancer (NMIBC). We evaluated the association between (changes in) PA (total, moderate\u2010to\u2010vigorous PA, leisure\u2010time PA, and Dutch PA guideline adherence) and risks of NMIBC recurrence and progression. Patients diagnosed between 2014 and 2021 were recruited for the multi\u2010center prospective cohort UroLife. Participants reported prediagnosis PA at 6\u2009weeks (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091414) and postdiagnosis PA at 3 and 15\u2009months after diagnosis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091275). Multivariable proportional hazards models were used to assess the association of PA levels with risk of first and multiple recurrence(s) and progression. During a median total follow\u2010up time of 4.6\u2009years, 501 patients had \u22651 recurrence, 144 had \u22652 recurrences, and 157 had progression. Higher pre\u2010 and postdiagnosis PA levels were not significantly associated with risks of first recurrence, multiple recurrences, and progression. Pre\u2010to\u2010postdiagnosis increases of 10 metabolic equivalent of task hour\/week in leisure\u2010time PA, equivalent to 3\u20134\u2009h\/week of walking or 1\u2009h\/week of running, were significantly associated with lower progression risk (hazard ratio at 3\u2009months: 0.94, 95% confidence interval: 0.89\u20130.99). The self\u2010reported and relatively high PA levels could have limited the detection of associations. In conclusion, higher PA levels before or after NMIBC diagnosis were not significantly associated with lower recurrence or progression risk. Although pre\u2010to\u2010postdiagnosis increases in leisure\u2010time PA were associated with lower progression risk, further research is necessary before specific PA recommendations can be formulated for patients with NMIBC.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70030","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T03:28:35Z","timestamp":1751254115000},"page":"2049-2060","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Physical activity and risks of recurrence and progression among patients with non\u2010muscle invasive bladder cancer"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8424-7638","authenticated-orcid":false,"given":"Ivy","family":"Beeren","sequence":"first","affiliation":[{"name":"IQ Health science department Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1480-1362","authenticated-orcid":false,"given":"Joann","family":"Kiebach","sequence":"additional","affiliation":[{"name":"IQ Health science department Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7461-6364","authenticated-orcid":false,"given":"Jasper P.","family":"Hof","sequence":"additional","affiliation":[{"name":"IQ Health science department Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurien M.","family":"Buffart","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-2147","authenticated-orcid":false,"given":"Katja K. H.","family":"Aben","sequence":"additional","affiliation":[{"name":"IQ Health science department Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organization  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Alfred","family":"Witjes","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8839-8601","authenticated-orcid":false,"given":"Antoine G.","family":"van der Heijden","sequence":"additional","affiliation":[{"name":"Department of Urology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-1326","authenticated-orcid":false,"given":"Lambertus A. L. 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