{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:32:50Z","timestamp":1792096370670,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004897","name":"European Organisation for Research and Treatment of Cancer","doi-asserted-by":"publisher","award":["EORTC1629"],"award-info":[{"award-number":["EORTC1629"]}],"id":[{"id":"10.13039\/501100004897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2025,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Head and neck cancer (HNC) patients may experience toxicities as a result of their treatment modality. While acute toxicities have been well documented, the prevalence of toxicities at long\u2010term follow\u2010up of HNC survivors is less clear. As part of a multi\u2010national, cross\u2010sectional study, HNC survivors at least 5\u2009years post\u2010diagnosis were invited to undergo a toxicity examination. Using the Common Terminology Criteria for Adverse Events (version 5), 33 toxicities were assessed. From 2019 to 2021, 1094 survivors from 26 sites in 11 countries completed the assessment. Eighty\u2010seven percent were from Europe, and most were survivors of oropharynx (35%), oral cavity (21%), or larynx cancer (19%). The majority had been diagnosed at stage III or IV (62%), and the median time since diagnosis was 8\u2009years (range 5\u201336). Most had been treated with surgery and radiotherapy with or without chemotherapy (38%). Six percent had no toxicities, and 26% had only mild toxicities. 68% had at least one moderate or severe late toxicity. Overall, the most frequent late toxicities at any grade were dry mouth (67%), soft tissue fibrosis (52%), dysphagia (51%), and voice alterations (39%). Fistulae, neck and face edema, and osteonecrosis of the jaws were present in very few survivors. Our study shows that the majority of HNC survivors experience moderate or severe late toxicities, but that the problems are concentrated in a small group of specific toxicities. Understanding the problems experienced in the long term can help better inform newly diagnosed patients as well as inform survivorship follow\u2010up initiatives.<\/jats:p>","DOI":"10.1002\/ijc.70033","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:25:14Z","timestamp":1753871114000},"page":"2061-2070","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Toxicities in long\u2010term survivors of head and neck cancer\u2014A multi\u2010national cross\u2010sectional analysis"],"prefix":"10.1002","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-5789","authenticated-orcid":false,"given":"Katherine J.","family":"Taylor","sequence":"first","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology, and Informatics University Medical Centre Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie 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Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Scricciolo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Ospedale dell'Angelo  Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department Otolaryngology\u2010Head and Neck Surgery Amsterdam UMC location Vrije Universiteit  Amsterdam the Netherlands"},{"name":"Cancer Center Amsterdam Treatment and Quality of Life  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma M.","family":"Verdonck\u2010de Leeuw","sequence":"additional","affiliation":[{"name":"Department Otolaryngology\u2010Head and Neck Surgery Amsterdam UMC location Vrije Universiteit  Amsterdam the Netherlands"},{"name":"Cancer Center Amsterdam Treatment and Quality of Life  Amsterdam The Netherlands"},{"name":"Department of Clinical, Neuro and Developmental Psychology Vrije Universiteit Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Fanetti","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Centro di Riferimento Oncologico di Aviano (CRO) IRCCS  Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Guntinas\u2010Lichius","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Inhestern","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Jena University Hospital  Jena Germany"},{"name":"Department of Otorhinolaryngology Oberhavelkliniken Hennigsdorf  Hennigsdorf 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Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Kiyota","sequence":"additional","affiliation":[{"name":"Cancer Center Kobe University Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\u2014Plastic Surgery University Medical Centre Mainz  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Bonomo","sequence":"additional","affiliation":[{"name":"Radiation Oncology Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Pinto","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Unit Istituto Nazionale Tumori\u2014IRCCS\u2014Fondazione G. 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