{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:10:44Z","timestamp":1792631444683,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Obesity has been associated with non\u2010Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B\u2010cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome\u2010wide association studies of European ancestry (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200910,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist\u2010to\u2010hip ratio (WHR), and waist\u2010to\u2010hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) =\u20091.18, 95% confidence interval (95% CI): 1.05\u20131.33,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (OR\n                    <jats:sub>per SD<\/jats:sub>\n                    \u2009=\u20091.12, 95% CI: 1.02\u20131.23,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70039","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T10:47:34Z","timestamp":1757069254000},"page":"45-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetically determined body mass index is associated with diffuse large B\u2010cell lymphoma in polygenic and Mendelian randomization analyses"],"prefix":"10.1002","volume":"158","author":[{"given":"Amy","family":"Moore","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of York  York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-8536","authenticated-orcid":false,"given":"Lauren R.","family":"Teras","sequence":"additional","affiliation":[{"name":"Department of Population Science American Cancer Society  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell J.","family":"Machiela","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Arias","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orestis A.","family":"Panagiotou","sequence":"additional","affiliation":[{"name":"Department of Health Services, Policy, and Practice Brown University School of Public Health  Providence Rhode Island USA"},{"name":"Center for Gerontology and Healthcare Research Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Monnereau","sequence":"additional","affiliation":[{"name":"Unit of Mixed Research (UMR1153) Centre for Research in Epidemiology and Statistics (CRESS), INSERM, Universit\u00e9 Paris\u2010Cit\u00e9  Paris France"},{"name":"Registre des h\u00e9mopathies malignes de la Gironde Institut Bergoni\u00e9  Bordeaux Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Wong","family":"Doo","sequence":"additional","affiliation":[{"name":"Concord Clinical School University of Sydney  Concord New South Wales Australia"},{"name":"Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-3869","authenticated-orcid":false,"given":"Zhaoming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Computational Biology St Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[{"name":"Quantitative Health Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel C. H.","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences Institute for Risk Assessment Sciences, Utrecht University  Utrecht The Netherlands"},{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3612-8298","authenticated-orcid":false,"given":"Claire M.","family":"Vajdic","sequence":"additional","affiliation":[{"name":"Surveillance and Evaluation Research Program The Kirby Institute, University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Department of Medicine, Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Hematology Center Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Cancer Control Research BC Cancer  Vancouver British Columbia Canada"},{"name":"School of Population and Public Health University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Vijai","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham G.","family":"Giles","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia"},{"name":"Centre for Epidemiology and Biostatistics Melbourne School of Population and Global Health, University of Melbourne  Melbourne Victoria Australia"},{"name":"Precision Medicine School of Clinical Sciences at Monash Health, Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Carver College of Medicine, The University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan A.","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology New York University School of Medicine  New York New York USA"},{"name":"Department of Environmental Medicine New York University School of Medicine  New York New York USA"},{"name":"Perlmutter Cancer Center NYU Langone Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Nieters","sequence":"additional","affiliation":[{"name":"Center for Chronic Immunodeficiency Institute for Immunodeficiency, University Medical Center Freiburg  Freiburg 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